Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study |
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| Authors: | Raj K. Kalapatapu Thomas C. Neylan Mathilda C. Regan Beth E. Cohen |
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| Affiliation: | 1. Department of Psychiatry, University of California, San Francisco, California, USA;2. San Francisco Veterans Affairs Medical Center, San Francisco, California, USAkalapatapu.raj.k@gmail.com;4. San Francisco Veterans Affairs Medical Center, San Francisco, California, USA;5. Northern California Institute for Research and Education, San Francisco, California, USA;6. San Francisco Veterans Affairs Medical Center, San Francisco, California, USA;7. Department of Medicine, University of California, San Francisco, California, USA |
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| Abstract: | The authors conducted a study of alcohol use biomarkers and cognitive performance among 85 veterans with problematic alcohol use and posttraumatic stress disorder (PTSD). All analyses were adjusted for demographics, depression, anxiety, and PTSD symptoms. Elevated levels of aspartate aminotransferase were associated with worse performance on the Trail Making Test Part A and Hopkins Verbal Learning Test. Two other biomarkers were not associated with any neurocognitive measures. Indirect alcohol use biomarkers (e.g., aspartate aminotransferase) may have a specific role in identifying veterans with problematic alcohol use and PTSD who show a change in psychomotor speed and immediate verbal memory performance. |
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| Keywords: | Alcohol use biomarkers cognitive performance problematic alcohol use posttraumatic stress disorder |
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