| Abstract: | Abstract: Diazoxide blood levels in man were measured after single 600 mg oral doses in solution, capsule and tablet form. A high correlation was found between dissolution rate in 0.1 N-HCl and area under the 0–6 hour blood level curve. Griseofulvin absorption from 10 different preparations was studied in man. Plasma levels were followed for 1 day after a single oral 500 mg dose, and for 7 days after daily 500 mg doses. A high correlation was found between dissolution rate in simulated intestinal fluid and area under the 0–25, 49–173, and 0–173 hour plasma level curves. |
