| 同型半胱氨酸及蛋氨酸合成酶基因多态性与颅内动脉瘤的关系 |
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| 引用本文： | 陈盛强,戴文伟,许绍强,孙卫文,邓维意,伍建伟,李明昌,何伟文,陆永健,罗学港. 同型半胱氨酸及蛋氨酸合成酶基因多态性与颅内动脉瘤的关系[J]. 广东医学, 2011, 32(13): 1675-1677 |
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| 作者姓名： | 陈盛强 戴文伟 许绍强 孙卫文 邓维意 伍建伟 李明昌 何伟文 陆永健 罗学港 |
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| 作者单位： | 陈盛强,戴文伟,孙卫文,邓维意,伍建伟,李明昌,何伟文,陆永健,CHEN Sheng-qiang,DAI Wen-wei,SUN Wei-wen,DENG Wei-yi,WU Jian-wei,LI Ming-chang,HE Wei-wen,LU Yong-jian(广州医学院第二附属医院神经科学研究所,广州,510260);许绍强,XU Shao-qiang(广州三九脑科医院检验科,广州,510510);罗学港,LUO Xue-gang(中南大学湘雅医学院人体解剖学和神经生物学系,长沙,410013) |
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| 摘 要： | 目的 探讨同型半胱氨酸(Hcy)及其代谢关键酶蛋氨酸合成酶(methionine synthase,MS)基因多态性与颅内动脉瘤的关系.方法 采用化学发光技术检测76例颅内动脉瘤患者和77例健康成人的血浆Hcy水平,并利用聚合酶链式反应技术检测其MS基因多态性.结果 颅内动脉瘤组血浆Hcy水平为(16.14±6.72)...
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| 关 键 词： | 同型半胱氨酸 颅内动脉瘤 蛋氨酸合成酶 多态性 |
The correlation between intracranial aneurysm and polymorphism of methionine synthase gene or plasma homocysteine level |
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| CHEN Sheng-qiang,DAI Wen-wei,XU Shao-qiang,SUN Wei-wen,DENG Wei-yi,WU Jian-wei,LI Ming-chang,HE Wei-wen,LU Yong-jian,LUO Xue-gang. The correlation between intracranial aneurysm and polymorphism of methionine synthase gene or plasma homocysteine level[J]. Guangdong Medical Journal, 2011, 32(13): 1675-1677 |
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| Authors: | CHEN Sheng-qiang DAI Wen-wei XU Shao-qiang SUN Wei-wen DENG Wei-yi WU Jian-wei LI Ming-chang HE Wei-wen LU Yong-jian LUO Xue-gang |
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| Abstract: | Objective To investigate the correlation between intracranial aneurysm and plasma homocysteine(Hcy) level or polymorphism of methionine synthase(MS). Methods MS genotype and plasma Hcy level was determined in 76 patients with intracranial aneurysm and 77 healthy controls. Results Significant higher plasma Hcy concentration and MS D919G DG frequency were revealed in intracranial aneurysm patients than that in controls(P<0.05).No significant difference in allele frequency was observed between the two groups(P... |
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| Keywords: | Homocysteine methionine synthase Intracranial aneurysm Polymorphism |
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