| 大豆苷元对离体心肌缺血/再灌注损伤时抗氧化作用的影响 |
| |
| 引用本文： | 王全华,李冬莲,黄志华.大豆苷元对离体心肌缺血/再灌注损伤时抗氧化作用的影响[J].赣南医学院学报,2011,31(2):189-191. |
| |
| 作者姓名： | 王全华 李冬莲 黄志华 |
| |
| 作者单位： | 王全华,李冬莲,WANG Quan-hua,LI Dong-lian(赣州市人民医院);黄志华,HUANG Zhi-hua(赣南医学院,江西赣州,341000) |
| |
| 摘 要： | 目的：研究大豆苷元对离体心脏缺血/再灌注损伤时抗氧化能力的影响。方法：应用大鼠离体心肌缺血再灌注损伤模型,在灌流液中加入高、中、低剂量的大豆苷元进行再灌注。再灌注结束后,测定心肌组织超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）的活性及丙二醛（MDA）的含量和心肌组织乳酸脱氢酶（LDH）和心肌肌酸激酶（CK）活性的变化。结果：低剂量的大豆苷元能提高心肌组织SOD、GSH-Px的活性,降低MDA含量;中剂量的大豆苷元能提高心肌组织GSH-PX的活性,降低MDA的含量,高剂量的大豆苷元能提高心肌组织SOD及GSH-PX的活性,也能降低MDA含量;大豆苷元能使心肌LDH及CK的活性升高。结论：大豆苷元可通过提高抗氧化酶系统的功能、加速氧自由基的清除而保护缺血再灌注心肌。
|
| 关 键 词： | 大豆苷元 缺血再灌注损伤 抗氧化作用 |
The Anti-oxidation Effects of daidzin on Isolated Myocardial Ischemia/Reperfusion Injury |
| |
| WANG Quan-hua,LI Dong-lian,HUANG Zhi-hua.The Anti-oxidation Effects of daidzin on Isolated Myocardial Ischemia/Reperfusion Injury[J].Journal of Gannan Medical College,2011,31(2):189-191. |
| |
| Authors: | WANG Quan-hua LI Dong-lian HUANG Zhi-hua |
| |
| Institution: | WANG Quan-hua,LI Dong-lian,HUANG Zhi-hua(1.Ganzhou People's Hospital,2.Gannan Medical University,Ganzhou,Jiangxi 341000) |
| |
| Abstract: | Objective:To explore the Anti-oxidation effects of daidzin on isolated myocardial ischemia/reperfusion injury.Methods:A rat myocardial ischemia/reperfusion injury was made and treated with daidzin(high dose,medium dose and low dose).Following the treatment,the concentration of malondialdehyde and the activities of superoxide dismutase and glutathion peroxidase were investigated;as well as the activities of lactate dehydrogenase and creatine kinase.Results:After treatment,it showed an increase in the enzymat... |
| |
| Keywords: | daidzin myocardial ischemia/reperfusion injury anti-oxidation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
