| 沙滩黄芩中的二萜类化合物 |
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| 引用本文： | 李桂生,郝鑫淼,张雷,岳喜典,戴胜军.沙滩黄芩中的二萜类化合物[J].中国中药杂志,2015,40(1):98-102. |
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| 作者姓名： | 李桂生 郝鑫淼 张雷 岳喜典 戴胜军 |
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| 作者单位： | 烟台大学 药学院, 山东 烟台 264005,烟台大学 药学院, 山东 烟台 264005,烟台大学 药学院, 山东 烟台 264005,烟台大学 药学院, 山东 烟台 264005,烟台大学 药学院, 山东 烟台 264005 |
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| 基金项目： | 国家自然科学基金项目(21372189);山东省自然科学基金项目(ZR2013HM023) |
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| 摘 要： | 应用硅胶柱色谱,Sephadex LH-20柱色谱及高效制备薄层色谱等方法对沙滩黄芩中的二萜单体进行分离纯化,根据理化性质和波谱数据对其化学结构进行阐明,发现并鉴定了9个二萜化合物,分别为6-乙酰氧基-7-烟酸酰氧基半枝莲碱 G(1),6-烟酸酰氧基-7-乙酰氧基半枝莲碱 G(2),6,7-二烟酸酰氧基半枝莲碱 G(3),半枝莲碱 K(4),半枝莲碱 B(5),6-乙酰氧基河南半枝莲碱A(6),6-烟酸酰氧基半枝莲素 A(7),6,7-二乙酰氧基半枝莲素 A(8),半枝莲碱 F(9)。化合物1为新化合物,化合物2 ~ 9均为首次从沙滩黄芩中发现。
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| 关 键 词： | 唇形科 黄芩属 沙滩黄芩 二萜 |
| 收稿时间： | 2014/9/19 0:00:00 |
Diterpenoids from Scutellaria strigillosa |
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| LI Gui-sheng,HAO Xin-miao,ZHANG Lei,YUE Xi-dian and DAI Sheng-jun.Diterpenoids from Scutellaria strigillosa[J].China Journal of Chinese Materia Medica,2015,40(1):98-102. |
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| Authors: | LI Gui-sheng HAO Xin-miao ZHANG Lei YUE Xi-dian and DAI Sheng-jun |
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| Institution: | School of Pharmaceutical Science, Yantai University, Yantai 264005, China,School of Pharmaceutical Science, Yantai University, Yantai 264005, China,School of Pharmaceutical Science, Yantai University, Yantai 264005, China,School of Pharmaceutical Science, Yantai University, Yantai 264005, China and School of Pharmaceutical Science, Yantai University, Yantai 264005, China |
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| Abstract: | By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20, nine diterpenoids were isolated and purified from the whole plants of Scutellaria strigillosa. Based on the physico-chemical properties and spectral data, their structures were elucidated as: 6-O-acetyl-7-O-nicotinoylscutebarbatine G(1), 6-O-nicotinoyl-7-O-acetylscutebarbatine G(2), 6, 7-di-O-nicotinoylscutebarbatine G(3), scutebarbatine K(4), scutebarbatine B(5), 6-O-acetylscutehenanine A(6), 6-O-nicotinoylbarbatin A(7), 6, 7-di-O-acetoxylbarbatin A(8), scutebarbatine F(9). Compound 1 is a new diterpenoid, and compounds 2 - 9 were isolated from Scutellaria strigillosa for the first time. |
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| Keywords: | Lamiaceae Scutellaria Scutellaria strigillosa diterpenoid |
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