| 国外天然产物化学成分实物库及数据库建设概况 |
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| 引用本文： | 赵丽梅,谭宁华. 国外天然产物化学成分实物库及数据库建设概况[J]. 中国中药杂志, 2015, 40(1): 29-35 |
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| 作者姓名： | 赵丽梅 谭宁华 |
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| 作者单位： | 中国科学院 昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室, 云南 昆明 650201,中国科学院 昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室, 云南 昆明 650201 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2011ZX09307-002-02);云南省自然科学基金项目(2012GA003) |
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| 摘 要： | 天然产物是新药发现的重要源泉,天然产物化学成分实物库和数据库的建设对天然产物的研究与开发具有重要意义。目前国外建设的小分子化合物库多为合成或组合合成分子,天然产物实物获取较困难。在信息数据库建设方面由于使用标准不同,信息不统一,开发规范、实用、智能型、综合型的大规模天然产物数据库还存在一定困难。该文就目前国外可以公开查询到的有关天然产物的实物库及数据库建设情况进行了概述和分析,以期对天然产物研究与开发,特别是天然产物化学成分实物库和数据库的建设提供参考。
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| 关 键 词： | 天然产物 实物库 数据库 |
| 收稿时间： | 2014-09-24 |
Status of libraries and databases for natural products at abroad |
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| ZHAO Li-mei and TAN Ning-hua. Status of libraries and databases for natural products at abroad[J]. China Journal of Chinese Materia Medica, 2015, 40(1): 29-35 |
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| Authors: | ZHAO Li-mei and TAN Ning-hua |
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| Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China and State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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| Abstract: | For natural products are one of the important sources for drug discovery, libraries and databases of natural products are significant for the development and research of natural products. At present, most of compound libraries at abroad are synthetic or combinatorial synthetic molecules, resulting to access natural products difficult; for information of natural products are scattered with different standards, it is difficult to construct convenient, comprehensive and large-scale databases for natural products. This paper reviewed the status of current accessing libraries and databases for natural products at abroad and provided some important information for the development of libraries and database for natural products. |
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| Keywords: | natural products compound library database |
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