PS2表达在判断乳腺癌预后和指导内分泌治疗中的价值

目的：检测PS2基因在乳腺癌组织中的表达，并探讨其对判断乳腺癌预后和指导内分泌治疗中的价值。方法：应用免疫组化S－P法检测89例乳腺癌组织中PS2、ER、PR蛋白的表达。结果：PS2阳性表达率为38．2％（34／89）；PS2基因的表达与肿瘤的组织学分级、腋淋巴结状况和月经 状况相关（P＜0．05）；单因素分析PS2、ER表达均与5年无瘤生存率和5年总生存率相关（P＜0．05）；PS2与ER、PR表达呈正相关（P＜0．01）；PS2、ER表达与内分泌治疗疗效相关（P＜0．01）。结论：在指导内分泌治疗时，PS2可以作为1个重要的指标补充ER、PR的不足，三者结合可进一步提高乳腺癌内分泌治疗的针对性和疗效；PS2对判断乳腺癌的预后有一定价值，但不是独立的预后指标。

Clinical Value of PS2 Expression in Evaluating Prognosis and Directing Endocrine Therapy of Breast Cancer

Objective To detect the expression of PS2 in breast cancer tissues and to explore its value in evaluating prognosis and directing endocrine therapy of breast cancer.Methods Immunochemistry S P method was used to detect the expressions of PS2,ER and PR in 89 cases of breast cancer.Results The positive rate of PS2 was 38.2%.The expression of PS2 was correlated with histologic grade,lymphnode metastasis and menses status( P <0.05).The expressions of PS2 and ER were related with 5 year DFS and 5 year OS in mono factor analysis( P <0.05).There was positive correlation among the expression of PS2,ER and PR( P <0.01).Expressions of PS2 and ER were related with the effect of endocrine therapy( P <0.01).Conclusion PS2 is an important marker to guide endocrine therapy,but it is not an independent index to evaluate prognosis of breast cancer.