灯盏生脉胶囊对缺血性视神经病变的疗效

目的探讨灯盏生脉胶囊对气虚血瘀型非动脉炎性前部缺血性视神经病变（NAION）的临床疗效。方法随机对照试验。将120例NAION患者分为对照组和治疗组，对照组60例（84眼），治疗组60例（85眼）。对照组给予复方樟柳碱注射液颞浅动脉旁注射，2 ml/次，1次/d。治疗组患者在上述治疗的基础上，加用灯盏生脉胶囊（口服，0.36 g/次，3次/d）进行治疗。治疗3个月后，观察并分析2组患者的总体疗效、视力、视野平均光敏感度以及血液流变学指标的改善情况。采用Wilcoxon 秩和检验、独立样本t检验、配对t检验进行数据分析。结果最终对照组和治疗组分别有49例（70眼）和51例（72眼）完成研究。治疗后，和对照组比较，治疗组患者视力（t=-5.223，P＜0.05）、视野平均敏感度（t=-3.690，P<0.05）较高；治疗组患者的血浆黏度、全血高切黏度、低切黏度、红细胞压积指数及血浆纤维蛋白原水平均较对照组低（t=1.224、3.114、7.458、9.153、2.105，P＜0.05）。治疗组患者视神经病变的总有效率为88%，显著高于对照组（71%）（Z=2.890，P＜0.01）。结论复方樟柳碱注射液联合灯盏生脉胶囊可显著改善NAION患者的视力、视野及血液流变学指标。

Clinical studies of the effect of a Dengzhan Shengmai capsules on non-arteritic ischemic optic neuropathy

Objective To evaluate the clinical efficacy of Dengzhan Shengmai capsules for patients with non-arteritic anterior ischemic optic neuropathy (NAION).Methods A total of 120 patients with NAION were enrolled in a randomized controlled trial.Of those,60 control patients were treated only with compound anisodine (CA,2 ml/injection,1 per day) (the control group),while the remaining 60 patients,designated,the combination group,received a combined treatment of CA and a Dengzhan Shengrnai capsule,0.36 g/dose,3 times/day (the combination group).Patients were followed for 3 months,and the overall curative effect,visual acuity,visual field mean sensitivity,and hemorheology indicators were measured.Data were analyzed using the Wilcoxon test and the t test.Results Forty-nine patients (70 eyes) in the control group and 51 patients (72 eyes) in the combination treatment group were followed for 3 months or more.Compared to the control group,the combination treatment produced significantly higher visual acuity and visual field mean sensitivity (t=-5.223,-3.690,P＜0.05).In the combination group the plasma viscosity,whole blood high shear viscosity,low shear viscosity,hematokrit,and plasma fibrin were significantly lower than in the control group (t=1.224,3.114,7.458,9.153,2.105,respectively,P＜0.05 for each).The total effective rates were 88％ and 71％ for the combination group and control group,respectively (Z=2.890,P＜0.01).Conclusion Our results show that a combination of CA and Dengzhan Shengrnai capsules improves visual acuity,visual field mean sensitivity and hemorheology indicators for NAION patients.