| 2型糖尿病肾病患者血清超敏C-反应蛋白、脂联素测定的临床意义 |
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| 引用本文： | 文洪林,邹文蓉,孟元,郭海,周梅,贺红.2型糖尿病肾病患者血清超敏C-反应蛋白、脂联素测定的临床意义[J].山西医科大学学报,2008,39(12):1121-1123. |
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| 作者姓名： | 文洪林 邹文蓉 孟元 郭海 周梅 贺红 |
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| 作者单位： | 1. 首都医科大学附属北京中医医院临床检验中心,北京,100010
2. 北京积水潭医院 |
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| 摘 要： | 目的 探讨超敏C-反应蛋白(hs-CRP)及脂联素在2型糖尿病肾病诊断中的水平变化、相互关系及临床应用价值.方法 选择2型糖尿病住院患者136例作为观察对象,并根据尿白蛋白排泄量分为3组:极微量白蛋白尿(n=42),微量白蛋白尿组(n=44),大量白蛋白尿组(n=50);同时选择健康体检者50例作为正常对照组.随后分别用胶乳增强免疫比浊法测定hs-CRP、ELISA法测定脂联素,同时测定空腹血糖(FBG)、血肌酐(Scr)、血脂水平、尿白蛋白(UAlb),比较各组间的差异.结果 2型糖尿病肾病组hs-CRP水平随尿白蛋白排泄量和Scr水平的增加而升高,而hs-CRP与血清脂联素水平呈负相关. 结论 hs-CRP及脂联素联合监测对于2型糖尿病早期肾损伤诊断有重要参考价值.
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| 关 键 词： | 超敏C-反应蛋白 脂联素 微量白蛋白 糖尿病肾病 |
Clinical significance of serum high sensitive C-reactive protein and adiponectin level in the diagnosis of type 2 diabetic patients with nephropathy |
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| WEN Hong-lin,ZOU Wen-rong,MENG Yuan,GUO Hai,ZHOU Mei,HE Hong.Clinical significance of serum high sensitive C-reactive protein and adiponectin level in the diagnosis of type 2 diabetic patients with nephropathy[J].Journal of Shanxi Medical University,2008,39(12):1121-1123. |
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| Authors: | WEN Hong-lin ZOU Wen-rong MENG Yuan GUO Hai ZHOU Mei HE Hong |
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| Institution: | 1Center of Clinical Laboratory;Beijing Traditional Chinese Medicine Hospital;Capital Medical University;Beijing 100010;China;2Beijing Jishuitan Hospital |
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| Abstract: | Objective To investigate relationship between serum adiponectin,high sensitive C-reactive protein(hs-CRP)and levels of urinary albumin(UAlb)excretion amount in type 2 diabetic patients with different stages of nephropathy. Methods A total of 136 type 2 diabetic patients with nephropathy and 50 normal healthy controls were enrolled in this study.According to UAlb excretion amount,these patients were divided into three groups:trace albuminura group(<30 mg/d,n=32),microalbuminura group(30-300 mg/d,n=44)and mac... |
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| Keywords: | high sensitive C-reactive protein adiponectin microalbumin diabetic nephropathy |
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