肿瘤坏死因子受体在大肠癌中的表达及其意义

目的　探讨大肠癌组织中肿瘤坏死因子受体 (TNFR2 )表达的数目与临床病理因素及肿瘤分期间的关系。方法　用免疫组织化学SABC法检测 97例大肠癌组织、81例癌旁组织及 13例正常肠粘膜中TNFR2 的表达。结果　大肠癌组织中TNFR2 表达比癌旁组织及正常组织显著高表达 (P <0 .0 0 1) ,且癌旁组织TNFR2 表达亦显著高于正常组织 (P <0 .0 5 )。在大肠癌组织中 ,TNFR2 表达与肿瘤分化程度和浆膜浸润无关 (r =- 0 .0 91,P =0 .44 3;r =0 .10 ,P =0 .396 ) ,而与淋巴结转移呈负相关 (r =- 0 .313,P =0 .0 0 7) ,即肿瘤有淋巴结转移时TNF2 表达低。同时 ,DukeA期和B期患者TNFR2 表达显著高于DukeC期 (P <0 .0 0 1)。结论　TNFR2 检测对判断大肠癌恶性程度 ,预测肿瘤淋巴结转移趋势及肿瘤分期有重要价值

Investigation of Tumor Necrosis Factor Receptor 2 Expression in Human Colorectal Cancer

Objective To study the clinical significance of Tumor Necrosis Factor Receptor 2(TNFR 2)expression and its relationship with clinical pathology and Duke's classification in Human colorectal cancer Method SABC immunohistochemical method was used to examine the positive rates of TNFR 2 in 97 cases of colorectal cancer、81 cases of its surrounding mucosa and 13 cases of normal tissue Result The positive rate of TNFR 2 expression in colorectal cancer was significantly higher than in surrounding mucosa and in normal tissue, further more TNFR 2 expression in surrounding mucosa was significantly higher than in normal tissue There was no correlations between differentiation grade, serous membrane invasion and the degree of TNFR 2 expression( r=-0.096, P=0.443;r=0.1, P =0.396) But there was negative correlations between lymph node metastasis and TNFR 1 expression( r=-0.3131, P =0.007) Significant difference was found between Duke's A, B and Duke's C( P <0.001) Conclusion TNFR 2 expression was important to determine the degree of malignancy, and predict lymph node metastasis and Duke's classification of colorectal cancer