| 托吡酯添加治疗儿童癫痫的临床观察 |
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| 引用本文： | 童光磊,李司南,鲍劲松,周陶成.托吡酯添加治疗儿童癫痫的临床观察[J].安徽卫生职业技术学院学报,2007,6(3):22-23,36. |
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| 作者姓名： | 童光磊 李司南 鲍劲松 周陶成 |
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| 作者单位： | 安徽省立儿童医院神经康复科,合肥,230051 |
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| 摘 要： | 目的:评价托吡酯(TPM)联合用药治疗儿童癫痫的疗效及安全性.方法:对72例儿童癫痫采用病例自身对照临床实验,进行个体用药观察.TPM的起始剂量为0.5～1.0 mg/(kg.d),加量1次/5～7 天,剂量为0.5～1.0 mg/(kg.d),目标剂量为4～8 mg/(g.d).结果:TPM添加治疗后3个月,总有效率为75.00%;6个月总有效率为83.33%;12个月总有效率为84.72%.结论:TPM联合用药治疗儿童癫痫有效率较高,是一种安全性好,不良反应轻的治疗方法.
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| 关 键 词： | 托吡酯 儿童 癫痫 |
| 文章编号： | 1671-8054(2007)03-0022-02 |
| 修稿时间： | 2007年2月27日 |
Clinical efficacy of combining topiramate in treatment of children epilepsy |
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| TONG Guang-lei,LI Si-nan,BAO Jin-song,ZHOU Tao-cheng.Clinical efficacy of combining topiramate in treatment of children epilepsy[J].Journal of Anhui Heaith Vocational & Technical College,2007,6(3):22-23,36. |
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| Authors: | TONG Guang-lei LI Si-nan BAO Jin-song ZHOU Tao-cheng |
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| Abstract: | Objective To assess the efficacy and safety of combine Topiramate(TPM) in patients with children epilepsy.Methods 72 patients were given TPM 0.5-1.0mg/kg once a day,increasing dose 0.5-1mg/kg.d(1 weeks),the targeted dosage was 4-8mg/(kg.d) TPM.Results Increasing TMP after 3 months,6 months,12 months,the above three indexes the significaant effective rate was 75%,83.33%,84.72%.There was significant difference after 3 months and 6 months(P< 0.05).There was no significant difference after 6 months and 12 months(P> 0.05).Conclusion combining TPM is an effective and safe therapy for treatment of epilepsy. |
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| Keywords: | Topiramate children epilepsy |
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