Effects of ethanol feeding and malnutrition on collagen synthesizing and degrading enzymes in rat pancreas |
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| Affiliation: | 1. Nutrition and Metabolism, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil;2. School of Physical Education of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil;3. Department of Physical Education, Faculty of Physical Education and Sport, State University of Londrina. Rodovia Celso Garcia Cid | Pr 445 Km 380 | Campus Universitário, Londrina, Paraná, Brazil;4. Department of Biochesmtry and Imunology, Faculty of Medicine of Ribeirão Preto Av. Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil;1. Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China;2. College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, PR China;3. Research Institute of Natural Gas Technology, Petro China Southwest Oil & Gas Field Company, Chengdu 610213, PR China;4. Department of Periodontics, West China Hospital of Stomatology, Sichuan University, 610041, PR China;1. Oulu Center for Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, FIN-90014 Oulu, Finland;2. Centre for Cancer Biomarkers CCBIO, Department of Biomedicine, University of Bergen, N-5009 Bergen, Norway;3. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA;4. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA |
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| Abstract: | This study was performed to delineate the combined effects of a low-fat diet and chronic ethanol ingestion on collagen metabolism in rat pancreas. Rats fed a very low-fat diet (5% of total calories as lipid) for 12 weeks developed malnutrition as judged by weight loss (−33% of the initial body weight) and low serum albumin and amylase levels. The pancreas of malnourished rats showed increased collagenase activity with respect to animals fed a 35% lipid diet (p < 0.05). Hydroxyproline content was higher in the pancreas of malnourished rats and collagenase activity correlated well with hydroxyproline content (r = 0.57, p = 0.0013). Ethanol feeding for 12 weeks, regardless of the nutritional state of the rats, did not change the synthesis and degradation rates of collagen in the pancreas. The present study suggests that malnutrition may have profound effects on collagen metabolism. |
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