Association between serum lactate dehydrogenase and 60‐day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study |
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Authors: | Zuomiao Xiao Rongpeng Gong Xianchun Chen Dejun Xiao Shi Luo Yanhong Ji |
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Affiliation: | 1. Department of Clinical Laboratory, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou China ; 2. Medical College of Qinghai University, Xining China ; 3. Department of Immunology& Microbiology, School of Medicine, Xi''an Jiaotong University, Xi''an Shaanxi China |
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Abstract: | BackgroundThere is evidence that a high level of serum lactate dehydrogenase (LDH) is associated with poorer overall survival in acute myeloid leukemia (AML), but its link to 60‐day mortality of AML remains unclear.MethodsAll patients newly diagnosed with AML were included in this cohort study. LDH was measured for the first time after admission. Multivariable logistic regression was used to explore the association between serum LDH and 60‐day mortality. Interaction and stratified analyses were conducted including age, sex, albumin, glucose, myoglobin, and standard chemotherapy.ResultsThree hundred and seventy‐one patients ≥15 years of age, who were newly diagnosed with AML, were consecutively selected. The total prevalence of 60‐day mortality was 27.2% (101/371), while it was 32.1% (42/131) and higher than in the LDH ≥570U/L compared with the LDH<570U/L, with the prevalence of 24.6% (59/240); however, the difference was not statistically significant. In multivariate regression models, odd ratios and corresponding 95% confidence intervals (CIs) for Log2 and twice limit of normal (ULN) of LDH were 1.46 (1.0, 2.14) and 2.76 (1.24, 6.16), respectively. Interaction analysis revealed no interactive role in the association between LDH concentration and 60‐day mortality.ConclusionsSerum LDH level was associated with 60‐day mortality, especially for the patients with LDH ≥570U/L. |
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Keywords: | acute myeloid leukemia (AML), lactate dehydrogenase (LDH), 60‐ day mortality |
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