Effects of ethanol intake on lipid metabolism in the lactating rat |
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| Institution: | 1. Instituto de Nutrição, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil;2. Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, SP, Brasil;3. Servicio de Bioquímica, Departamento de Investigación, Hospital Ramón y Cajal, Madrid, Spain;4. Centro de Ciencias Experimentales y Técnicas, Universidad San Pablo-CEU, Madrid, Spain;1. Centro de Investigación Cardiovascular (CSIC-ICCC). IIB-Sant Pau, Barcelona, España;2. CIBER de Enfermedades Cardiovasculares, España;3. Departamento de Farmacología, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, España;1. Division of Sleep Medicine, Stanford University, 450 Broadway Pavillion C 2nd Floor, Redwood City, CA 94063, USA;2. Division of Child-Psychiatry and Pediatric-Sleep laboratory, Department of Psychiatry, Chang Gung Memorial Hospital and Medical College, No. 5, Fuxing Street, Guishan, Taoyuan 333, Linkou, Taiwan;1. Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran;2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran;1. Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada;2. Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada;1. School of Public Health, China Medical University, Shenyang, Liaoning, PR China;2. The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China;3. The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA;4. Rollins School of Public Health, Emory University, Atlanta, GA, USA;5. Graduate School of Medicine, Tohoku University, Sendai, Japan |
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| Abstract: | Female rats receiving alcohol (20%) in drinking water during lactation (AL) were compared to pair-fed animals (PF) and normal controls (C) fed ad lib. All animals were killed on the 12th day of lactation. When compared to C rats, food intake decreased in both AL and PF groups, and this effect was followed by a lower body weight and mammary gland (MG), liver, and parametrial adipose tissue weights. Mammary glands triacylglyceride concentration (TG) was much lower in PF than in AL, although in the latter, values did not reach those of C, and had higher liver TG concentration than any of the other groups. Both PF and AL rats had lower plasma TG, glycerol, and free fatty acid concentrations and higher β;-hydroxybutyrate concentration than C rats. When compared to C rats, the rate of lipogenesis in MG was higher in both PF and AL rats, whereas in liver it was higher in PF and lower in AL rats, and in adipose tissue it was higher in PF and unchanged in AL rats. The appearance of 14C lipids 4 h after oral 14] triolein in both MG and liver was lower in AL and PF rats and only lower in adipose tissue of AL rats as compared to the C rats. Lipoprotein lipase and hormone-sensitive lipase activities were lower in MG in both PF and AL rats than in C, whereas in adipose tissue the activity of lipoprotein lipase did not differ between AL and C rats and the activity of HSL was lower in the former. These findings therefore show that in spite of reduced uptake of orally administered triglycerides due to decreased LPL activity, maternal alcohol feeding during lactation in the rat preserves the mammary gland triglyceride content thanks to enhanced lipogenetic activity. On the other hand, it causes liver triglycerides accumulation, probably as a result of the decreased rate of triglycerides released into circulation, and these changes are not caused by the reduced food intake of the animals. |
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