An fMRI study of musicians with focal dystonia during tapping tasks |
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| Authors: | Hiroshi Kadota Yasoichi Nakajima Makoto Miyazaki Hirofumi Sekiguchi Yutaka Kohno Masatoshi Amako Hiroshi Arino Koichi Nemoto Naotaka Sakai |
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| Affiliation: | (1) Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa Saitama, 359-8555, Japan;(2) Course of Functional Control Systems, Graduate School of Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama Satitama, 337-8570, Japan;(3) Present address: Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;(4) Research Institute, Kochi University of Technology, 185 Miyanokuchi, Tosayamada, Kochi 782-8502, Japan;(5) Faculty of Business and Information Sciences, Jobu University, 634-1, Toyatsuka-machi, Isesaki Gunma, 372-8588, Japan;(6) Ibaraki Prefectural University of Health Sciences, 4733 Ami, Ami-machi, Inashiki Ibaraki, 300-0331, Japan;(7) Department of Orthopaedic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa Saitama, 359-8513, Japan;(8) National Defense Medical College Research Institute, National Defense Medical College, 3-2 Namiki, Tokorozawa Saitama 359-8513, Japan;(9) Department of Mechanical and Intelligent Engineering, Graduate School of Engineering, Utsunomiya University, 7-1-2 Yoto, Utsunomiya 321-8585, Japan;(10) Department of Orthopedic Surgery, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama Kanagawa, 236-0004, Japan |
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| Abstract: | Musician’s dystonia is a type of task specific dystonia for which the pathophysiology is not clear. In this study, we performed functional magnetic resonance imaging to investigate the motor-related brain activity associated with musician’s dystonia. We compared brain activities measured from subjects with focal hand dystonia and normal (control) musicians during right-hand, left-hand, and both-hands tapping tasks. We found activations in the thalamus and the basal ganglia during the tapping tasks in the control group but not in the dystonia group. For both groups, we detected significant activations in the contralateral sensorimotor areas, including the premotor area and cerebellum, during each tapping task. Moreover, direct comparison between the dystonia and control groups showed that the dystonia group had greater activity in the ipsilateral premotor area during the right-hand tapping task and less activity in the left cerebellum during the both-hands tapping task. Thus, the dystonic musicians showed irregular activation patterns in the motor-association system. We suggest that irregular neural activity patterns in dystonic subjects reflect dystonic neural malfunction and consequent compensatory activity to maintain appropriate voluntary movements. |
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