ESR1 and EGF genetic variation in relation to breast cancer risk and survival |
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Authors: | Einarsdóttir Kristjana Darabi Hatef Li Yi Low Yen Ling Li Yu Qing Bonnard Carine Sjölander Arvid Czene Kamila Wedrén Sara Liu Edison T Hall Per Humphreys Keith Liu Jianjun |
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Affiliation: | Kristjana Einarsdóttir, Hatef Darabi, Yi Li, Yen Ling Low, Yu Qing Li, Carine Bonnard, Arvid Sjölander, Kamila Czene, Sara Wedrén, Edison T Liu, Per Hall, Keith Humphreys, and Jianjun Liu |
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Abstract: | IntroductionOestrogen exposure is a central factor in the development of breast cancer. Oestrogen receptor alpha (ESR1) is the main mediator of oestrogen effect in breast epithelia and has also been shown to be activated by epidermal growth factor (EGF). We sought to determine if common genetic variation in the ESR1 and EGF genes affects breast cancer risk, tumour characteristics or breast cancer survival.MethodsWe genotyped 157 single nucleotide polymorphisms (SNPs) in ESR1 and 54 SNPs in EGF in 92 Swedish controls and selected haplotype tagging SNPs (tagSNPs) that could predict both single SNP and haplotype variation in the genes with an R2 of at least 0.8. The tagSNPs were genotyped in 1,590 breast cancer cases and 1,518 controls, and their association with breast cancer risk, tumour characteristics and survival were assessed using unconditional logistic regression models, Cox proportional hazard models and haplotype analysis.ResultsThe single tagSNP analysis did not reveal association evidence for breast cancer risk, tumour characteristics, or survival. A multi-locus analysis of five adjacent tagSNPs suggested a region in ESR1 (between rs3003925 and rs2144025) for association with breast cancer risk (p = 0.001), but the result did not withstand adjustment for multiple comparisons (p = 0.086). A similar region was also implicated by haplotype analyses, but its significance needs to be verified by follow-up analysis.ConclusionOur results do not support a strong association between common variants in the ESR1 and EGF genes and breast cancer risk, tumour characteristics or survival. |
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