CYP4F2基因单核苷酸多态性与日本高血压的相关性研究

目的:研究在不同性别中,CYP4F2基因单核苷酸多态性与日本高血压的关系。方法:249例日本原发性高血压患者和207例年龄匹配的对照(日本人)分别分为整体组、男性组、女性组。选择CYPF2基因的5个SNPs(rs3093105、rs3093135、rs1558139、rs2108622、rs3093200),应用TaqManSNP基因分型的方法进行基因分型,分析CYP4F2基因单核苷酸多态性与高血压的相关性。结果:高血压患者和对照相比较,rs1558139基因型的显性模式分布(CCversusCT TT)在整体组和男性组中显著不同(P=0.037,P=0.005),高血压患者的CC基因型频率显著高于对照的CC基因型频率。Logistic回归分析显示,在剔除高血压主要危险因素的干扰后,男性组rs1558139的CC基因型分布在高血压患者和对照之间仍然保持差异(P=0.026),而整体组高血压患者和对照之间CC基因型分布的差异消失(P=0.247)。对于男性,高血压组的C等位基因频率显著高于对照组(P=0.025)。结论:CYP4F2基因rs1558139的CC基因型和C等位基因可做为日本男性高血压的基因标记。

Association between the SNPs of human CYP4F2 gene and essential hypertension in Japan

Objective:The aim of the present study was to assess the association between the human CYP4F2 gene and essential hypartension(EH)in Japanese,using a case-control study that included a separate analysis of the gender groups.Methods:There were 249 EH patients and 238 age-matched controls genotyped for 5 SNPs of the human CYP4F2 gene(rs3093105,rs3093135,rs1558139,rs2108622,rs3093200).The data were assessed for 3 separate groups:the total subjects,men and women.Results:For the total and men subjects,the distribution of the dominant model of rs1558139(CC versus CT TT)differed significantly between the EH patients and control subjects(P=0.037,P=0.005,respectively),the CC genotype was higher in the EH patients than in the control subjects.Logistic regression showed that for the men,the CC genotype of rs1558139 keep higher in EH patients than in the control subjects(P=0.026),while for the total,the difference was disappeared(P=0.247).For men subjects,C allele is significantly higher in EH patients than the control subjects(P=0.025).Conclusions:In conclusion,the CC genotype and C allele of rs1558139 can be genetic marker of EH in Japanese men.