| 伪麻黄碱水杨酸盐的合成研究 |
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| 引用本文： | 吴桂荣,林伟. 伪麻黄碱水杨酸盐的合成研究[J]. 中国药物化学杂志, 2001, 11(4): 236-237 |
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| 作者姓名： | 吴桂荣 林伟 |
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| 作者单位： | 新疆医科大学药学院 |
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| 基金项目： | 新疆维吾尔自治区科委资助课题(G943105),专利申请号:961030089 |
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| 摘 要： | 采用A、B两种方法对伪麻黄碱水杨酸盐的合成工艺进行了研究。用正交设计筛选工艺条件，用红外光谱跟踪合成产物。结果表明，合成方法B比合成方法A好。B法具有收率高（88.1%)、操作简便、无需有机溶剂=不污染环境等优点。是一条理想的合成路线。
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| 关 键 词： | 右旋伪麻黄碱 水杨酸钠 合成 收率 |
| 文章编号： | 1005-0108(2001)04-0236-02 |
Research on the Synthesis of the( + )-Pseudophedrinium salicylate |
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| WU Gui-rong,LIN Wei. Research on the Synthesis of the( + )-Pseudophedrinium salicylate[J]. Chinese Journal of Medicinal Chemistry, 2001, 11(4): 236-237 |
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| Authors: | WU Gui-rong LIN Wei |
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| Abstract: | Two synthetic routes of the( )-pseudophedrinium s al icylate were studied.This paper is to select the conditions of the reaction by u sing orthogona l design;to determine the process of the reaction by the chromatographic sheet;t o identify the structure of the product on IR.The synthetic routes of the( )-ps eudophedrinium salicylate by using sodium salicylate as the material are better than that of the salicylic acid.The yield was 881%. |
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| Keywords: | sodium salicylate ( )-pseudoephedrine synthesis yi eld |
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