非外阴部位硬化萎缩性苔藓11例临床及反射式共聚焦显微镜特征分析

目的 探讨非外阴部位硬化萎缩性苔藓的临床特点及反射式共聚焦显微镜特征。方法 回顾分析沈阳市第七人民医院皮肤科和中国医科大学附属第一医院皮肤科2010 年10月至2016年10月诊治的11例非外阴部位硬化萎缩性苔藓患者临床及反射式共聚焦显微镜资料。结果 11例中9例为女性，6例发生于颈部。反射式共聚焦显微镜图像显示，表皮萎缩，基底层高反光消失，基底层环状结构缺失，真表皮界限模糊不清，真皮浅层散在高反光类圆形大细胞及少量单一核细胞，胶原均质化并密度增加。结论 非外阴部位硬化萎缩性苔藓在反射式共聚焦显微镜下有特征性表现。

Clinical and reflectance confocal microscopy features of 11 cases of extragenital lichen sclerosus et atrophicus

Guo Chunfang, Chen Guang, Li Tie′nan, Sun Xiaojie, Jin Chunlin, Wang ZhenDepartment of Dermatology, Shenyang No.7 People′s Hospital, Shenyang 110003, China （Guo CF, Li TN, Sun XJ, Jin CL, Wang Z）; Department of Dermatology, The First Hospital of China Medical University, Shenyang 110001, China （Chen G）Corresponding author: Chen Guang, Email: dr.cg@126.com【Abstract】 Objective To investigate clinical and reflectance confocal microscopy（RCM）features of extragenital lichen sclerosus et atrophicus. Methods Clinical data and RCM images were collected from 11 patients with extragenital lichen sclerosus et atrophicus in Department of Dermatology of Shenyang No.7 People′s Hospital and the First Hospital of China Medical University between October 2010 and October 2016, and retrospectively analyzed. Results Of the 11 patients, 9 were female, and 6 had lesions on the neck. RCM imaging showed atrophy of the epidermis, disappearance of high reflectivity and circular structures in the basal layer, blurred dermo-epidermal junction, highly reflective quasi-circular big cells and a few mononuclear cells scattering in the superficial dermis, and homogenization and increased density of collagen. Conclusion Extragenital lichen sclerosus et atrophicus has characteristic RCM presentation.