20例早产儿支气管肺发育不良的危险因素分析

目的 分析不同程度的早产儿支气管肺发育不良的危险因素。方法 回顾性分析西安医学院第二附属医院NICU室2017年5月至2018年8月收治的＜32周早产儿,出院明确诊断为支气管肺发育不良20例,分为轻度组(11例)和中重度组(9例),搜集20例患儿母亲产前(子痫、糖尿病、胎盘早剥、早破水、绒毛膜炎、产前激素的使用),新生儿相关资料(胎龄、出生体重、小于胎龄儿),治疗相关资料(PS、PS给药方式(LISA/INSRUE)、枸橼酸咖啡因、糖皮质激素、机械通气＜7d、用氧浓度＞40%且≥14d),利用单因素及多因素Logist分析综合评判主要影响因素。结果 单因素分析显示:子痫、绒毛膜炎、产前激素、胎龄、出生体重、PS给药方式、用氧浓度＞40%且≥14d、机械通气＜7d,P＜0.01;多因素分析显示:绒毛膜炎、胎龄、机械通气＜7d,P ＜0.01,其中绒毛膜炎、胎龄是危险因素,机械通气＜7d是保护因素。结论 预防感染,防止早产,减少机械通气时间可减轻气管肺发育不良的程度。

Analysis of risk factors for bronchopulmonary dysplasia in 20 premature infants

Objective To analyze the risk factors of different degrees of bronchopulmonary dysplasia in premature infants.Methods Retrospective analysis of the ＜32 weeks of preterm infants admitted to the NICU room of the Second Affiliated Hospital of Xi'an Medical College from May 2017 to November 2018.The hospital was diagnosed as having bronchopulmonary dysplasia in 20 cases,divided into mild group (11 cases) and moderately severe group (9 case).20 cases of mothers were collected prenatal data (eclampsia,diabetes,placental abruption,early water break,chorioamnion,prenatal hormone use),neonatal related data (gestational age,birth weight,small for gestational age),treatment-related data (PS,PS administration (LISA/INSRUE),caffeine citrate,glucocorticoids,mechanical ventilation ＜7 d,oxygen concentration ＞40% and ≥14d).The main influencing factors were comprehensively evaluated by single factor and multi-factor Logist analysis.Results Univariate analysis showed: eclampsia,chorioamnionitis,prenatal hormone,gestational age,birth weight,PS administration,oxygen concentration ＞40% and ≥14 d,mechanical ventilation ＜7 d,P＜0.01; multivariate analysis showed : chorioamnionitis,gestational age,mechanical ventilation ＜7 d,P＜0.01.Among them,chorioamnionitis and gestational age were risk factors,and mechanical ventilation ＜7 d was a protective factor.Conclusion Preventing infection,preventing premature birth,and reducing mechanical ventilation time can reduce the degree of tracheal lung dysplasia.