| 内质网应激PERK通路在肿瘤中的研究进展 |
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| 引用本文： | 欧阳仲瑞,柴双,赵海杞,刘耀华. 内质网应激PERK通路在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(1): 38-41. DOI: 10.11904/j.issn.1002-3070.2018.01.007 |
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| 作者姓名： | 欧阳仲瑞 柴双 赵海杞 刘耀华 |
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| 作者单位： | 1.哈尔滨医科大学附属第一医院神经外科(哈尔滨 150001);2.内蒙古扎兰屯中蒙医院神经外科 |
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| 基金项目： | 国家自然科学基金(81372701) |
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| 摘 要： | 肿瘤细胞在生长、浸润和转移过程中经历的缺氧、低糖等多种环境压力会对肿瘤细胞造成内质网应激,为应对内质网应激,肿瘤细胞会诱发未折叠蛋白反应(Unfolded protein response,UPR)。PERK通路作为激活UPR的一条关键通路可通过提高肿瘤对不良微环境的耐受程度、诱导新生血管生成、诱导自噬体形成、激活凋亡信号分子等促进肿瘤细胞生长、增殖、侵袭及保护性自噬,并且在UPR达到一定程度时诱导肿瘤细胞凋亡及自噬性死亡。
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| 关 键 词： | 内质网应激未折叠蛋白反应 肿瘤细胞 PERK通路 |
| 收稿时间： | 2017-09-19 |
Research progress of PERK signaling pathway under endoplasmic reticulum stress in tumor |
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| OUYANG Zhongrui,CHAI Shuang,ZHAO Haiqi,LIU Yaohua. Research progress of PERK signaling pathway under endoplasmic reticulum stress in tumor[J]. Journal of Practical Oncology, 2018, 32(1): 38-41. DOI: 10.11904/j.issn.1002-3070.2018.01.007 |
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| Authors: | OUYANG Zhongrui CHAI Shuang ZHAO Haiqi LIU Yaohua |
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| Affiliation: | 1.Department of Neurosurgery,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2.Department of Neurosurgery,Zhalantun Traditional Chinese,Inn-Mongolia Medicine Hospital |
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| Abstract: | During growth,invasion and metastasis,tumor cells undergo endoplasmic reticulum stress(ERS)under hypoxia,hypoglycemia and other environmental stresses.In response to ERS,tumor cells induce unfolded protein response(UPR).PERK signaling pathway as a key pathway to activate UPR can promote survival,proliferation,invasion and protection of tumor cells by increasing tumor tolerance to adverse microenvironment,inducting angiogenesis,inducing autophagosome formation and activating apoptotic signal molecules.Tumor cells are induced apoptotic and autophagic death when UPR reaches a certain extent. |
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| Keywords: | ERS UPR Tumor cells PERK signaling pathway |
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