毛发扁平苔藓三例分析

目的 探讨毛发扁平苔藓的临床和组织病理特征。方法 分析3例毛发扁平苔藓患者的临床、组织病理学特征。结果 3例患者均为女性，平均年龄49岁。1例患者临床表现为额部、顶部及枕部大面积斑片状脱发，2例表现为头皮不规则斑片状脱发及皮肤萎缩。1例患者除头发外，眉毛、腋毛亦脱落。组织病理均为毛囊壁基底层细胞液化变性及淋巴细胞浸润。1例血管附件周围亦可见少量淋巴细胞浸润。结论 毛发扁平苔藓可仅累及头皮，亦可累及全身其他部位皮肤，多表现为头皮斑片状脱发伴皮肤萎缩。病理学典型改变为毛囊基底细胞液化变性，淋巴细胞浸润。

Clinical and pathological analysis of three cases of lichen planopilaris

Su Ting, Chen Yiwen, Sun Yaqi, Zhang Meihua, Su Zhonglan Department of Dermatology, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Corresponding author: Su Zhonglan, Email: susustyle1990@163.com 【Abstract】 Objective To investigate clinical and histopathological features of lichen planopilaris（LPP）. Methods The clinical and histopathological findings in 3 cases of LPP were analyzed. Results All the 3 patients were female, and their average age was 49 years. One patient presented with large-area patchy hair loss on the frontal, parietal and occipital region, and 2 patients presented with irregular patchy hair loss on the scalp and skin atrophy. Besides the hair loss, the eyebrows and axillary hairs also lost in 1 patient. Histopathological examination showed liquefaction degeneration of basal cells in the walls of hair follicles and infiltration of lymphocytes. Infiltration of a small number of lymphocytes was also observed around blood vessels and appendages. Conclusions LPP may only affect the scalp, or involve the other sites all over the body. LPP commonly manifests as patchy hair loss on the scalp and skin atrophy, and is pathologically characterized by liquefaction degeneration of basal cells in hair follicles and infiltration of lymphocytes.