聚乙二醇电解质溶液分次与单次口服肠道准备方案的清洁效果和耐受性比较

目的 比较结肠镜检查患者分次与单次口服聚乙二醇电解质溶液进行肠道准备的清洁效果和耐受性。 方法 将进行结肠镜检查的120例患者采用随机法分为A组（单次口服）和B组（分次口服）。A组于检查前5 h单次口服3 L聚乙二醇电解质溶液；B组于检查前夜和检查前4 h分次口服1.5 L聚乙二醇电解质溶液。结肠镜检查时分别对结肠的3个解剖分段处（左半结肠、横结肠、右半结肠）进行Boston肠道准备量表评分，并在检查结束后记录120例患者服药期间的耐受性、依从性、不良反应发生率进行比较分析。 结果 两组患肠道准备方案均达到结肠镜检查要求，Boston肠道准备量表评分相似（P>0.05），但B组Boston肠道准备量表评分较A组有明显差异（P<0.01）。两组患者耐受性及不良反应发生率的结果显示B组优于A组（P<0.05）。 结论 分次口服聚乙二醇电解质溶液的肠道清洁准备方案在取得满意的清洁效果同时患者耐受性更好，不良反应发生率更低，值得临床推广应用。  

Comparative study of the cleaning effect and tolerance of fractionated dose and single dose polyethylene glycol electrolyte solution bowel preparation

Objective To compare the cleaning effect and tolerance of bowel preparations with fractionated dose versus single dose polyethylene glycol electrolyte solution (PEG-ES) bowel preparation regimens for colonoscopy. Methods 120 patients who received colonoscopy in our hospital from April 2016 to September 2016 were randomly divided into two groups. Subjects in group A received a single dose of 3L PEG-ES before examination, and subjects in group B drank 1.5 L PEG-ES on the eve and 4 hours before colonoscopy. Score and degree of Boston bowel preparation scale (BBPS) and PEG-ES related adverse effects of the two groups were assessed. Results T Both regimens met the requirements of colonoscopy. The BBPS score was similar (P>0.05),but the score of BBPS was significant higher in group B than in group A (P<0.01). The result of tolerance and adverse reaction test showed that group B was also significantly better than group A (P<0.05). Conclusion Fragmented dose PEG-ES regimen provides a better colonic cleansing quality and tolerance for bowel preparation of colonoscopy, which is superior to that od single dose regimen.