诱发膀胱癌的常见慢性炎症因素及其免疫治疗的研究进展

越来越多的证据表明,不可控制的炎症与肿瘤发生、发展有着密切的关系,其中慢性炎症可能在包括膀胱癌在内的各种恶性肿瘤中发挥关键作用。膀胱癌是泌尿系统最常见的恶性肿瘤,对于非肌层浸润性膀胱癌经尿道膀胱肿瘤切除术仍是主要手段,但其术后易复发,复发后恶性度逐渐增加,故术后需辅助性药物治疗,降低其复发与进展。如今免疫治疗成为研究热点,并取得较好效果。本文就诱发膀胱癌的常见慢性炎症因素及其免疫治疗相关研究做一简述。

Progress in common chronic inflammatory factors inducing bladder cancer and its immunotherapy

More and more evidence shows that uncontrollable inflammation has closely associated with tumorigenesis and development.Chronic inflammation may play a key role in various malignant tumors including bladder cancer.Bladder cancer is the most common malignant tumor of the urinary system.For non-muscle-invasive bladder cancer,the main method is still transurethral resection of bladder tumors,but its recurrence after surgery,the degree of malignancy after recurrence is gradually increased,so the need for postoperative adjuvant drug treatment reduces its recurrence and progression.Nowdays,immunotherapy has become a research hotspot and has achieved good effects.This article briefly describes the common chronic inflammation factors that induce bladder cancer and the related progression on immunotherapy.