双岐杆菌三联活菌散联合布拉氏酵母菌散治疗小儿抗生素相关性腹泻的临床疗效

目的 研究小儿应用抗生素联合益生菌治疗对于抗生素相关性腹泻的预防作用。方法 随机将2018年1月至2019年2月100例接受抗生素治疗的患儿分为两组,对照组50例,仅接受抗生素治疗,观察组50例,另外联合应用益生菌治疗,比较两组治疗效果。结果 治疗后抗生素相关性腹泻发生率与发生时间分别为:观察组4.00%,(13.96±1.17)d,对照组为20.00%、(10.59±1.02)d,P＜0.05;观察组治疗后大肠埃希菌、乳酸杆菌、双歧杆菌较治疗前变化不明显,P＞0.05,但高于对照组治疗后,P＜0.05;观察组治疗后IgG、IgA、IgM水平高于对照组,P＜0.05。结论 在应用抗生素治疗基础上联合益生菌治疗能够降低小儿抗生素相关性腹泻发生率,延迟其发生时间,同时能够改善患儿免疫功能,减小肠道菌群的波动。

Effect of antibiotics plus probiotics on prevention of antibiotic-associated diarrhea in children

Objective To study the preventive effect of antibiotics combined with probiotics in children on antibiotic-associated diarrhea.Methods 100 children who received antibiotics from January 2018 to February 2019 were randomly divided into 2 groups.In the control group,50 patients were treated with antibiotics alone,and 50 patients in the observation group were treated with probiotics.The therapeutic effects of the two groups were compared.Results The incidence of antibiotic-associated diarrhea in the observation group was 4.00%,the time of antibiotic-associated diarrhea was (13.96±1.17) d,the control group was 20.00%,(10.59±1.02) d,P<0.05; the observation group was treated with large intestine The changes of H.,Lactobacillus and Bifidobacteria were not obvious before treatment,P＞0.05,but higher than that of the control group,P＜0.05.The levels of IgG,IgA and IgM in the observation group were higher than those in the control group,P＜0.05.Conclusion The combination of probiotics on the basis of antibiotic therapy can reduce the incidence of antibiotic-associated diarrhea in children,delay the occurrence of it,and improve the immune function of children and reduce the fluctuation of intestinal flora.