血清中免疫球蛋白检验在乙型肝炎诊治中的意义及对预后的影响

目的 针对乙型肝炎患者,检测血清中免疫球蛋白水平,分析其在患者诊治及预后中的价值和意义,为临床提供参考依据。方法 选取铜川市人民医院2018年1月至12月收治的150例乙型肝炎患者作为研究对象,根据病情分为慢性重型乙型肝炎和慢性乙型肝炎,均为75例。另选取同期健康体检显示正常的75例体检者视为健康体检组。检测3组患者的IgA、IgG、IgM等免疫球蛋白水平并进行比较。对全部乙型肝炎患者进行治疗,根据病情进展进行分组,分为改善组(104例)和非改善组(46例)。检测两组患者的各免疫球蛋白水平和总胆红素(TBIL)水平和凝血酶原的活动度(PTA)水平。结果 3组IgA、IgG、IgM水平比较,慢性重型乙型肝炎组高于慢性乙型肝炎组和健康体检者,慢性乙型肝炎组高于健康体检组,差异均有统计学意义(P＜0.05)。改善组IgA、IgG、IgM水平和TBIL水平低于非改善组,PTA水平高于改善组,差异有统计学意义(P＜0.05)。结论 血清中免疫球蛋白检验对乙型肝炎的诊治及预后意义重大,临床针对乙型肝炎患者应加强对免疫球蛋白水平的检测,从而提高诊治的水平,改善患者预后。

Significance of serum immunoglobulin test in diagnosis andtreatment of hepatitis B and its effect on prognosis

Objective For hepatitis B patients,the serum immunoglobulin level was detected,and its value and significance in the diagnosis,treatment and prognosis of patients were analyzed,so as to provide a reference basis for clinical practice.Methods A total of 150 patients with hepatitis B admitted to our hospital from January 2018 to December 2018 were selected as study subjects.According to their conditions,they were divided into chronic severe hepatitis B and chronic hepatitis B,both of which were 75 cases.In addition,75 patients who received normal physical examination in our hospital during the same period were selected as the health examination group.IgA,IgG,IgM and other immunoglobulin levels in the three groups were detected and compared.All patients with hepatitis B were treated and divided into an improved group (104 cases) and a non-improved group (46 cases) according to disease progression.The levels of immunoglobulin,total bilirubin (TBIL) and prothrombin activity (PTA) in the two groups were detected.Results The levels of IgA,IgG and IgM in the chronic severe hepatitis B group,chronic hepatitis B group and the healthy screening group were higher than those in the chronic severe hepatitis B group and the healthy screening group,and the differences were statistically significant (P＜0.05).IgA,IgG,IgM and TBIL levels in the improved group were lower than those in the non-improved group,and PTA levels were higher than those in the improved group,with statistically significant differences (P＜0.05).Conclusion The serum immunoglobulin test is of great significance for the diagnosis and treatment of hepatitis B and the prognosis.The clinical examination of hepatitis B patients should strengthen the detection of immunoglobulin levels,thereby improving the level of diagnosis and treatment and improving the prognosis of patients.