ceRNAs在结直肠癌中的研究进展

结直肠癌在我国乃至全球范围发生率和死亡率都居于前列，严重危害着人体的健康，虽然结直肠癌的诊断和治疗技术不断提高，但中晚期结直肠癌患者的生存期仍然不佳，因此需要深入理解结直肠癌的发生发展机制，竞争内源性RNA理论的提出加深了对肿瘤形成机制的理解。竞争内源性RNA理论认为假基因转录本、长链非编码RNA、环状RNA、mRNA能作为竞争性内源性RNA，它们拥有编码蛋白mRNA相同microRNA反应元件，能竞争结合microRNA的结合位点，影响功能蛋白的表达而发挥促癌或抑癌的作用。近来大量研究表明竞争性内源性RNA分子在结直肠癌恶性行为中发挥重要功能，因此有必要对这些研究进行归纳梳理，本文目的在于将这些在结直肠癌中研究的竞争性内源性RNA分子进行归类，并阐述这些分子在结直肠癌中的作用。

Progress of CeRNAs in colorectal cancer

Colorectal cancer has a high morbidity and mortality both in China and world, which seriously endangers human health. Although the diagnosis and treatment techniques for colorectal cancer have been improved, the survival time of patients with advanced colorectal cancer is still poor. It is necessary to understand the mechanism of colorectal cancer. The competing endogenous RNA theory has deepened the understanding of the mechanism of tumor formation. The competing endogenous RNA (ceRNA) theory points out that psedugenic RNA、LncRNA、circRNA、mRNA, harbouring miRNA response element (MRE). It can act as ceRNA by competing for shared miRNAs to regular protein expression and promote/inhibit cancer. Recently, a large number of studies have shown that ceRNA molecules play an important role in the malignant behavior of colorectal cancer. It is necessary to summarize these studies. The purpose of this paper is to classify these ceRNA molecules in colorectal cancer and to elaborate the functions of these molecules in colorectal cancer.