滨海新区婴幼儿血流感染病原菌分析

目的:研究婴幼儿血流感染的病原菌组成及阳性报警时间，为血流感染的早期诊断与抗生素合理应用提供依据。方法:选取滨海新区疑似血流感染患儿943例，经血培养分析病原菌种类及对临床常用药物的敏感性。结果:非重复菌株共收集到91株，其中位居前3名的是22株凝固酶阴性葡萄球菌（CoNS）、14株大肠埃希菌和8株无乳链球菌。未分离到万古霉素、利奈唑胺和替加环素耐药的革兰氏阳性球菌，大肠埃希菌和肺炎克雷伯菌对头孢替坦、亚胺培南、哌拉西林/他唑巴坦、美洛培南和阿米卡星的敏感性为100%。阴沟肠杆菌的TTP（8.96±2.24） h]最短，光滑假丝酵母菌的TTP（44.4±16.59）h]最长。结论:滨海新区婴幼儿血流感染主要是革兰阳性菌，病原菌对常用的抗菌药物敏感性较高，临床医生应根据试验结果选择合理的抗菌药物。

Pathogenic bacteria in bloodstream infection in infants in Binhai New Area

Objective: To study the composition of pathogenic bacteria and the time to positive（TTP） of infants bloodstream infection and to provide basis for the early diagnosis of bloodstream infection and the appropriate application of antibiotics. Methods: Nine hundred and forty-three infants with suspected bloodstream infection were selected, and blood culture was used to analyze the types of pathogenic bacteria and the sensitivity to commonly used drugs. Results: A total of 91 non-repetitive strains were collected, of which 22 were coagulase-negative staphylococci, 14 strains of Escherichia coli and 8 strains of Streptococcus agalactiae; No vancomycin, linezolid and tigecycline-resistant gram-positive cocci were isolated. Escherichia coli and klebsiella pneumoniae were 100% sensitive to ceftiptin, imipenem, piperacillin/tazobactam, meropinam and amikacin. The TTP of enterobacter cloacae(8.96+2.24)h] was the shortest, and the TTP of candida glabratas was the longest(44.4+16.59) h]. Conclusion: In Binhai New Area, Gram-positive bacteria are the main pathogenic bacteria in infants with bloodstream infections. The pathogenic bacteria are highly sensitive to the common antibacterial drugs, and the clinical doctors should choose proper antimicrobial agents according to the test results.