心房颤动患者CA-125表达水平及其意义

目的：探讨CA-125在阵发性和持续性心房颤动（简称房颤）患者中的表达水平及其意义。方法：回顾性分析2017年6月至2018年6月在温州医科大学附属第一医院住院的642例房颤患者临床资料。将入组房颤患者根据阵发/持续房颤分为2组，比较临床资料（年龄、性别、BMI、房颤病程、左房内径、射血分数、BNP、肝肾功能、CHA2DS2-VASc评分、CA-125等），应用多因素logistic回归分析持续性房颤的危险因素。结果：与阵发性房颤患者相比，持续性房颤患者的CA-125水平更高（P＜0.001）。Logistic回归分析显示CA-125是持续性房颤的独立危险因素（P＜0.05）。结论：CA-125可能是持续性房颤的预测指标。

The significance of CA-125 level in atrial fibrillation

Objective: To investigate the significance of CA-125 in patients with paroxysmal and persistent atrial fibrillation (AF). Methods: A retrospective study was made of 642 patients admitted to the First Affiliated Hospital of Wenzhou Medical University (China) from June 2017 to June 2018. All subjects enrolled were divided into two groups according to episode/persistent AF and they were compared in paroxysmal AF and persistent AF. Their clinical data (age, gender, BMI, duration of AF, left atrial diameter, ejection fraction, BNP, liver and kidney function, CHA2DS2-VASc score, CA-125, etc.) were analyzed to identify the risk factors of persistent AF by multivariate regression analysis. Results: Statistical regression results showed that patients with persistent AF had higher levels of CA-125 (P<0.001) compared with patients with paroxysmal AF. Logistic regression analyses showed that CA-125 levels appeared to be unaffected by age, LAD, ejection fraction, sex and so on. Conclusion: Patients with persistent AF have higher CA-125 level.