2017年广州地区新诊断2型糖尿病、糖耐量异常危险因素病例对照研究

目的 探索2017年新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)、糖耐量异常(impaired glucose tolerance,IGR)危险因素,为T2DM的防治措施提供依据。方法 选择新诊断T2DM456名,按性别相同、年龄差小于5岁随机选择IGR和正常糖耐量(normal glucose tolerance,NGT)各456名,用多类结果logistic回归和有序多分类logistic回归分析T2DM和IGR的影响因素。结果 有序多分类logistic回归显示消瘦(OR=2.060,95%CI:1.020~4.162)、超重(OR=1.478,95%CI:1.181~1.849)、肥胖(OR=2.151,95%CI:1.561~2.965)、饮酒(OR=1.521,95%CI:1.093~2.117)、体力劳动者(OR=1.892,95%CI:1.317~2.718)是糖尿病疾病程度的危险因素,已婚(β=-0.591,OR=0.554,95%CI:0.385~0.795),运动(β=-0.336,OR=0.715,95%CI:0.579~0.883)是糖尿病疾病程度的保护因素;结合T2DM-NGT对照、T2DM-IGR对照、IGR-NGT对照3组比较,体力劳动者是糖尿病的危险人群,运动、饮酒、已婚的影响在IGR到T2DM阶段,在NGT转为IGR过程中作用较弱,而BMI影响NGT-IGR-T2DM整个过程。结论 超重与肥胖是糖尿病整个病程的危险因素,体力劳动者是糖尿病的危险人群,已婚、运动是糖尿病的保护因素,饮酒是糖尿病的危险因素。

A case-control study on the risk factors for newly diagnosed type 2 diabetes and impaired glucose tolerance in Guangzhou,2017

Objective To explore the factors affecting the newly diagnosed type 2 diabetes mellitus(T2DM)and impaired glucose tolerance(IGR)in 2017,and to provide a basis for the prevention and treatment of T2DM.Methods 456 new diagnosed type 2 diabetes mellitus were selected,and 456 patients with the same gender and age difference of fewer than 5 years were randomly selected for IGR and normal glucose tolerance(NGT).The multivariate logistic regression and ordered multi-class logistic regression were used to analyze the influencing factors of T2DM and IGR.Results Ordered multi-class logistic regression showed that thin(OR=2.060,95%CI:1.020~4.162),overweight(OR=1.478,95%CI:1.181~1.849),obesity(OR=2.151,95%CI:1.561~2.965),drink(OR=1.521,95%CI:1.093~2.117)and manual workers(OR=1.892,95%CI:1.317~2.718)were risk factors for diabetes disease.Married(β=-0.591,OR=0.554,95%CI:0.385~0.795)and exercise(β=-0.336,OR=0.715,95%CI:0.579~0.883)were the degree of diabetes protective factors.Compared with the T2DM-NGT control,T2DM-IGR control,and IGR-NGT control group,manual workers were at risk for diabetes.The effects of exercise,drinking,and marriage was in the IGR to T2DM stage.They were weaker in the process of converting NGT to IGR,and BMI affected the whole process of NGT-IGR-T2DM.Conclusion Overweight and obesity are risk factors for diabetes.The manual workers are at risk for diabetes.Married and exercise are protective factors for diabetes.Drinking is a risk factor for diabetes.