| 中国广西涠洲岛海域海绵Callyspongia sp.的化学成分研究 |
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| 引用本文： | 徐宝娟,王世玉,唐生安,王 雪.中国广西涠洲岛海域海绵Callyspongia sp.的化学成分研究[J].天津医科大学学报,2018,0(6):489-491. |
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| 作者姓名： | 徐宝娟 王世玉 唐生安 王 雪 |
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| 作者单位： | （1.天津医科大学第二医院药学部，天津 300211；2.天津医科大学药学院，天津市临床药物关键技术重点实验室，天津 300070） |
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| 摘 要： | 目的:对采自中国广西涠洲岛海域海绵Callyspongia sp.的化学成分进行分离和结构鉴定。方法:采用硅胶薄层色谱、柱色谱、凝胶渗透色谱LH-20，半制备HPLC等方法对采自中国广西涠洲岛海域海绵Callyspongia sp.的次生代谢产物进行化学分离，并通过核磁共振谱(1D、2D NMR)、质谱 (ESI - MS)等方法，确定化合物的结构。结果:共分离得到8个化合物，分别为牛磺酸（1）、乙酰牛磺酸（2）、N-甲基吡啶-2-羧酸盐（3）、zooanemonin（4）、N-丁基乙酰胺（5）、尿嘧啶（6）、3-甲基尿嘧啶（7）、苯甲酸（8）。结论:化合物1-5和7-8均为首次从该属海绵中分离得到。
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| 关 键 词： | Callyspongiasp 色谱分离 |
Study on the chemical components of the marine sponge Callyspongia sp. collected from the Weizhou island in Guangxi |
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| XU Bao-juan,WANG Shi-yu,TANG Sheng-an,WANG Xue.Study on the chemical components of the marine sponge Callyspongia sp. collected from the Weizhou island in Guangxi[J].Journal of Tianjin Medical University,2018,0(6):489-491. |
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| Authors: | XU Bao-juan WANG Shi-yu TANG Sheng-an WANG Xue |
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| Institution: | （1. Department of pharmacy, The Second Hospital, Tianjin Medical University, Tianjin 300211, China; 2. School of Pharmacy, Tianjin Medical University,Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin 300070, China） |
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| Abstract: | Objective: To study the chemical constituents from the marine sponge Callyspongia sp. collected from the Weizhou island in Guangxi. Methods: Various chromatography techniques were performed for the isolation and purification of the MeOH extracts. Their structures were determined mainly by extensive 1D and 2D NMR, MS analysis. Results: The isolated 8 compounds were elucidated as follows: taurine (1),N-acetyltaurine(2),N-methylpyridine-2-carboxylic salt(3),zooanemonin(4), N-butylacetamide (5), uracil(6), 3-methyluracil (7), andbenzoic acid(8). Conclusion: Compounds1-5,7-8 have been isolated from the genus Callyspongia for the first time. |
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| Keywords: | marine sponge Callyspongiasp chromatographic separation |
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