顺尔宁佐治儿童分泌性中耳炎的临床疗效

目的 探讨顺尔宁佐治儿童分泌性中耳炎的临床疗效。 方法 选择我院2013年3月~2014年3月保守治疗的分泌性中耳炎患儿100例，所有入组患儿均符合分泌性中耳炎诊断标准，随机分为对照组和治疗组，各50例，对照组患儿给予静脉滴注头孢哌酮治疗，2次/d，治疗组在对照组的基础上辅以顺尔宁口服治疗，1次/d，每天于患儿睡前口服。比较两组的患耳疼痛、鼓膜膨隆内陷、中耳腔渗液及听力好转、体征消失时间。 结果 治疗组在患耳疼痛、鼓膜膨隆内陷及中耳腔渗液消失、听力好转时间比对照组短，治疗组和对照组总有效率为98%、82%，两组差异有统计学意义（P<0.01）；治疗组与对照组患儿治疗后患儿及家属满意度分别为100%、84%，差异具有统计学意义（P<0.05）。 结论 顺尔宁佐治儿童分泌性中耳炎疗效确切，未见不良反应，值得临床推广使用。  

Clinical efficacy of montelukast in the treatment of children with secretory otitis media

Objective To evaluate the clinical efficacy of montelukast in the treatment of children with secretory otitis media (SOM). Methods 100 children with confirmed SOM admitted to our hospital from March 2013 to March 2014 were included. They were randomly divided into control group and treatment group, with 50 cases in each group. While both groups received intravenous infusion of cefoperazone twice a day, the treatment group also received additional oral administration of montelukast once a day before sleep. Clinical symptoms and the duration that signs and symptoms disappeared were compared. Results The signs and symptoms, including earache, invagination of swelled tympanic membrane and exudate in the middle ear cavity, disappeared sooner in the treatment group than that in the control group, and the treatment group exhibited a shorter hearing recovery time than that of the control group. The effective rates of the treatment and control group were 98% and 82% respectively, which showed a significant difference (P<0.01). The degrees of family member satisfaction after treatment for the treatment and control group were 100% and 84% respectively (P<0.05). Conclusion The curative effect of montelukast in the treatment of children with secretory otitis media is obvious with no adverse reactions, thus worthy to be recommended for clinical applications.