原发性肝细胞癌患者 TACE治疗前后血清血小板源性生长因子 -BB水平变化及其临床意义

目的　探讨原发性肝细胞癌（HCC）患者经皮肝动脉化疗栓塞（TACE）治疗前后血清血小板源性生长因子 （PDGF）-BB 的变化情况及其与近期疗效的关系。方法　选取2016 年1 月~2018 年10 月采用TACE 治疗的172 例 HCC 患者为观察组，另选取同期80 例健康体检者作为对照组，采用酶联免疫吸附试验法（ELISA）检测血清中PDGFBB 水平。结果　观察组患者术前、术后1 天、1 周和1 月的血清PDGF-BB 水平均显著高于对照组，差异均具有统计 学意义(P ＜ 0.01)。TACE 术前观察组患者的血清PDGF-BB 水平与肿瘤数目、肿瘤大小和有无癌栓相关(P ＜ 0.05)。 TACE 术后观察组患者的疗效与肿瘤数目、肿瘤大小、有无癌栓、术前血清AFP 水平和术后1 周血清PDGF-BB 水平显 著相关( 均P ＜ 0.05)。Logistic 多因素分析结果显示术后1 周血清PDGF-BB(OR=2.665, 95%CI: 1.231~5.769, P =0.000) 和肿瘤数目(OR=1.904, 95%CI: 1.023~3.544, P =0.005) 均是影响TACE 术后疗效的因素。结论　血清中PDGF-BB 水平与 TACE 术后HCC 患者的短期疗效密切相关。

Changes of Serum Platelet-Derived Growth Factor-BB Level before and after TACE Treatment in Patients with Primary Hepatocellular Carcinoma and Its Clinical Significance

Objective　To investigate the changes of serum platelet-derived growth factor (PDGF) -BB before and after transcatheter arterial chemoembolization (TACE) in patients with primary hepatocellular carcinoma (HCC) and its relationship with short-term efficacy. Methods　A total of 172 HCC patients treated with TACE in their hospital from January 2016 to October 2018 were selected as the observation group, and 80 healthy patients in their hospital during the same period were selected as the control group, and serum PDGF-BB level was detected by ELISA. Results　The serum PDGF-BB level in the observation group was significantly higher than that in the control group (P <0.01). The serum PDGF-BB level of patients in the preoperative TACE observation group was correlated with the number of tumors, tumor size and the presence or absence of tumor thrombus (P <0.05). The efficacy of patients in the observation group after TACE was significantly correlated with tumor number, tumor size, tumor embolism, serum AFP level before surgery and serum PDGF-BB level 1 week after surgery (all P <0.05). Logistic multivariate analysis showed that serum PDGF-BB level at 1 week after the operation (OR=2.665, 95% CI: 1.231~5.769, P =0.000) and tumor number (OR=1.904, 95% CI: 1.023~3.544, P =0.005) were both factors affecting the postoperative efficacy of TACE. Conclusion　Serum PDGF-BB level is closely related to the short-term efficacy of HCC patients after TACE.