Serotonin transporter gene polymorphism and the phenotypic heterogeneity of adult ADHD |
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| Authors: | E H Grevet F Z C Marques C A I Salgado A G Fischer K L Kalil M M Victor C R Garcia N O Sousa P Belmonte-de-Abreu C H D Bau |
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| Institution: | (1) Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil;(2) Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;(3) Departamento de Psiquiatria, Faculdade de Medicina, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil |
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| Abstract: | Summary The present study investigates possible associations between the 5-HTT control region polymorphism (5-HTTLPR) with adult ADHD,
including subtypes, severity, temperament profile and comorbidities. The polymorphic site was genotyped in 312 adult patients
with ADHD and 236 controls, all of them Brazilians of European descent. The interviews followed the DSM-IV criteria, using
the K-SADS-E for ADHD and oppositional defiant disorder, SCID-I and MINI for comorbidities and the TCI for temperament dimensions.
The 5-HTTLPR polymorphism was not associated with ADHD. Carriers of the S allele presented slightly higher inattention and
novelty seeking scores, and a higher frequency of drug dependence. These differences do not persist after correction for multiple
comparisons. These results suggest that the 5-HTTLPR polymorphism does not have a direct role in the predisposition to adult
ADHD. There is suggestive evidence for a small effect in some behavioral phenotypes related to ADHD. |
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| Keywords: | : Personality serotonin inattention temperament severity comorbidity |
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