Temocapril, an angiotensin converting enzyme inhibitor, protects against diabetes-induced endothelial dysfunction |
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Authors: | Pieper G M Siebeneich W |
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Institution: | Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Froedtert Memorial Hospital, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. |
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Abstract: | The effect of chronic treatment with the angiotensin converting enzyme inhibitor, temocapril, on prevention of endothelial dysfunction was evaluated in an experimental model of diabetes mellitus. Endothelium-dependent relaxation to acetylcholine was impaired while endothelium-independent relaxation to nitroglycerin was unaltered in diabetic aortic ring segments. Treatment of diabetic animals with temocapril prevented the impaired endothelium-dependent relaxation without altering responses to nitroglycerin. Acetylcholine-induced relaxation was largely due to nitric oxide (NO)-mediated relaxation; however, a small but significant portion of relaxation in aortic rings from temocapril-treated diabetic rats was resistant to inhibition by the nitric oxide synthase (NOS) inhibitor, L-nitroarginine. |
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