岗松挥发油对实验性肝损害的防治作用

本研究表明,岗松油对四氯化碳、硫代乙酰胺、醋酸强的松龙引起的小鼠SGPT升高有明显的降低作用,使BSP潴留量减少,相应肝组织病变减轻。此外,岗松油对四氯化碳损害小鼠和正常小鼠戊巴比妥钠的睡眠时间均能明显缩短。对巴豆油引起小鼠耳部炎症有明显的抗炎作用。岗松油的毒性很低,口服半数致死量(LD₅₀为3,758±539mg/kg,给兔灌胃687～1030mg/kg每天一次,连续30天,一般表现、血象、肝肾功能及病理检查均未见明显的改变。

STUDIES ON THE EFFECT OF THE ESSENTIAL OIL OF GANGSONG (BAECKEA FRUTESCENS L.) AGAINST EXPERIMENTAL LIVER INJURY IN MICE

The essential oil of Gangsong, a light yellow liquid obta. ined by steam distillation of leaves of Baeckea frutescens L., was found to be effective in lowering the elevated SGPT induced by CCl₄, TAA and prednisolone. Prior oral administration of the oil 435 mg/kg twice a day to CCl₄ or TAA-intoxicated mice produced a marked decrease of SGPT and BSP retention. Histological examination showed that hepatic damages of the essential oil pretreated mice were less severe than those of CCl₄ control group. The oil was found to have no direct inhibitory action on SGPT activity in vitro. In addition, the oil was shown to shorten sodium pentobarbitat sleeping time in both normal and CCl₄ intoxicated mice. The data indicate that the essential oil of Gangsong exerts a protective effect against CCl₄, TAA and prednisoione induced hepatic injury in mice. In addition, the essential oil exhibited inhibitory effect on croton oil induced ear inflammation in mice.The toxicity Ofothe essential oil was found to be low, the oral LD₅₀ was found to be 3758±539 mg/kg in mice. No marked toxic effect after administration of the oil to rabbits(687～1030 mg/kg) for 30 days was observed.