Effects of mianserin on human sleep |
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| Authors: | Y Maeda T Hayashi H Furuta Y Kim K Morikawa N Ishiguro K Ueno J Sano N Yamaguchi |
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| Institution: | Department of Neuropsychiatry, School of Medicine, Kanazawa University, Japan. |
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| Abstract: | Sleep EEG and nocturnal penile tumescence (NPT) were investigated in 6 healthy men during placebo and mianserin administration and after mianserin withdrawal. The results were assessed in a historical comparison with those previously obtained with clomipramine. With mianserin, REM sleep was suppressed slightly. However, the suppressive effect of mianserin on REM sleep--based on the historical comparison--was significantly weaker than that of clomipramine throughout all the drug nights. Accordingly, a rebound increase in REM sleep was not observed after withdrawal. Less suppressive effects on NPT and disturbance of sexual function with mianserin than with clomipramine were observed. We suggest that a correlation between the prolonging effect on REM latency and the clinical antidepressant effect is limited to some antidepressants. |
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