复方多黏菌素B软膏在老年非手术糖尿病足溃疡创面修复中的应用

目的探讨复方多黏菌素B软膏在老年糖尿病足溃疡创面非手术修复中的应用。方法 128例老年糖尿病足患者根据创面使用药物不同随机分为试验组(复方多黏菌素B组)及对照组(磺胺嘧啶银组),每组64例。分别在开始治疗后1、2、3、4周观察比较两组患者创面组织细菌定量、创面愈合率及表皮生长因子的表达。结果 (1)在开始治疗后3周时试验组患者创面组织细菌定量均值小于对照组(P<0.05),第4周后明显小于对照组(P<0.01);(2)两组患者创面愈合率在治疗1、2、3周后无统计学差异,4周后试验组创面愈合率明显高于对照组(P<0.01);(3)治疗3周后两组患者创面的表皮生长因子比较有统计学差异(P<0.05),第4周差异更明显(P<0.01)。结论复方多黏菌素B软膏适用于全身感染已被控制但局部感染较重、高龄、基础病变多、难以承受多次麻醉手术清创后植皮封闭创面的老年患者,对治疗修复糖尿病足溃疡创面是一种安全、有效、简易的外用药物。

Application of compound B multi-fungal ointment hormone in elderly non-surgical wound healing in diabetic foot ulcers

Objective To investigate the compound polymyxin B ointment application operation repair in non senile diabetic foot ulcers. Methods 128 cases of elderly patients with diabetic foot wound using drugs according to different randomly divided into experimental group（compound compound nystatin group）, and control group （silver sulfadiazine group）, each group of 64 cases. In the expression of 1 weeks after treatment, 2 weeks, 3 weeks, 4 weeks were compared between the two groups of patients the wound tissue bacterial quantity, wound healing rate and the expression of epidermal growth factor. Results （1） In 3 weeks after the start of treatment when the patients in experimental group wound tissue bacterial quantity mean less than that of the control group （P〈0.05）, after fourth weeks was significantly less than the control group（P〈0.01）; （2） Two groups of patients the wound healing rate in the treatment of 1, 2, 3 weeks had no obvious difference, was significantly higher than that in control group, the experimental group was after 4 weeks of healing（P〈0.01）; （3） 3 weeks after the treatment, two patients with epidermal growth factor was statistically significant（P〈0.05）, fourth weeks had significant difference （P〈0.01）. Conclusions Compound nystatin B ointment applied to systemic infection has been controlled, but local infection is heavy, old base lesions, difficult to withstand repeated anesthesia operation after debridement and skin grafting wound closure in elderly patients. The compound multi nystatin ointment topical B is a safe, effective, easy to repair and treatment of diabetes foot ulcer.