高血压与颈动脉粥样硬化相关性的研究进展

原发性高血压是一种全球性多发性疾病,起初是以血压升高为主要表现,继而伴有多个靶器官功能损害和代谢紊乱的全身性疾病。原发性高血压是动脉粥样硬化的独立危险因素,可导致主动脉、颈动脉、脑动脉、冠状动脉、肾动脉、肠系膜动脉及四肢动脉等的粥样硬化,从而引发脑血管意外、冠状动脉粥样硬化性心脏病、慢性肾功能不全等严重疾病。颈动脉较为表浅,病变出现较早,颈动脉内膜‐中膜厚度的改变及粥样斑块情况可较好地反映原发性高血压对全身动脉粥样硬化的影响,以及不同血压水平与动脉粥样硬化发生的关系。因此,对原发性高血压患者颈动脉病变的早期识别和准确评价,对疾病的早期防治和疗效评估及预后有重大意义。

Relationship between level of blood pressure and intima-media thickness of carotid artery

The primary hypertension （PH） is a global multiple diseases, initially the main performance are blood pressure, then accompanied by multiple target organ damage and metabolic disorders of systemic disease. PH is an independent risk factor for atherosclerosis, which can lead atherosclerosis of aorta, carotid, cerebral artery, coronary, renal artery, superior mesenteric artery and limbs artery, causing cerebral vascular accident, coronary atherosclerotic heart disease, chronic renal failure and other serious diseases. Carotid artery is relatively superficial, the lesions appear earlier, and the examinations arc noninvasive, convenient and accurate. The change of carotid intima-media thickness and atheromatous plaque, may well reflect the influence of PH on systemic atherosclerosis, as well as the relationship between different blood pressure and atherosclerosis. Therefore, early recognition and accurate assessment on carotid artery disease of patients with PH, would have great significance on early prevention, efficacy evaluation and prognosis of the disease.