Effect of intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis |
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Authors: | Etsuji Shiota Kuniyoshi Tsuchiya Kazuhiro Yamaoka Osamu Kawano |
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Institution: | (1) Department of Orthopaedic Surgery,Chikushi Hospital, Fukuoka University, 377-1 Zokumyoin, Chikushino, Fukuoka 818-8502, Japan, JP;(2) Department of Orthopaedic Surgery, Saiseikai Yahata Hospital, Kitakyushu 805-0050, Japan, JP |
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Abstract: | We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal
osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture. The patients were 40
women, over 50 years of age, with lumbo-dorsal pain and low BMD (less than 0.70 g/cm2), measured by dual-energy X-ray absorptiometry (DXA). The patients were randomly assigned to two groups. The first group
(HEBP) received 200 mg of HEBP per day for 2 weeks, followed by 2 g calcium lactate and 0.5 μg alphacalcidol per day for the
next 10 weeks. This 12-week cycle was repeated eight times for 2 years. The second group (Ca · D) received 2 g calcium lactate
and 0.5 μg alphacalcidol per day for 2 years. Lumbar BMD was measured before the treatment and every 6 months during the treatment
until 24 months, and changes were evaluated. The number of fractured vertebrae was counted on X-ray films before treatment
and at the final assessment. After 6 months of treatment, a significant and continuous increase in BMD was observed in the
HEBP group. Moreover, the percentage of patients with new vertebral compression fractures in the HEBP group was one-tenth
of that in the Ca · D group. These results suggest that intermittent cyclical treatment with HEBP and calcium plus alphacalcidol
may be effective for increasing BMD and preventing fractures in postmenopausal osteoporosis.
Received: May 19, 2000 / Accepted: October 18, 2000 |
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Keywords: | Osteoporosis Bisphosphonate Dual-energy X-ray absorptiometry (DXA) Fracture incidence Bone mineral density |
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