Reduced-antigen-content-diphtheria-tetanus-acellular-pertussis and inactivated polio vaccine as a booster for adolescents 10 to 14 years of age |
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Authors: | Email author" target="_blank">Rodrigo?VergaraEmail author Miguel?Tregnaghi José?Ussher Sofía?Navarro Ricardo?Rüttimann Marcela?Potin Joanne?Wolter Lode?Schuerman |
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Institution: | (1) Escuela de Medicina, Universidad de Valparaíso, Hontaneda 2653, Oficina 318, Valparaíso, Chile;(2) Centro de Desarrollo de Proyectos, Avanzados en Pediatría, Córdoba, Argentina;(3) Hontaneda 2653, Oficina 318, Valparaíso, Chile;(4) GlaxoSmithKline Biologicals, Buenos Aires, Argentina;(5) Department of Paediatrics, School of Medicine, Universidad Católica de Chile, Santiago, Chile;(6) GlaxoSmithKline Biologicals, Rixensart, Belgium |
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Abstract: | High rates of pertussis disease in adolescents suggest that additional boosting against pertussis would be beneficial. A combined acellular-pertussis-containing booster vaccine (dTpa-IPV; Boostrix Polio, n =440) was compared to separately administered dTpa (Boostrix ) and inactivated polio virus (IPV; Imovax Polio®, n =219), and to DTPa-IPV (Infanrix IPV, n =111) vaccine in a partially blind, randomised controlled trial in 10–14 year olds. One month after vaccination, seroprotection/seropositivity rates for all antigens were similar for all groups. Although pertussis and diphtheria antibody geometric mean antibody concentrations were higher after DTPa-IPV, all subjects had protective antibodies against diphtheria, tetanus and polio, and at least 97% had a vaccine response to pertussis antigens. Reactogenicity of dTpa-IPV was comparable to dTpa + IPV, but dTpa-IPV was generally better tolerated than DTPa-IPV. Conclusion:The combined reduced-antigen-content-diphtheria-tetanus-acellular-pertussis and IPV vaccine is immunogenic and well tolerated when administered to adolescents and could be used to improve the control of pertussis disease in this age group. |
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Keywords: | Adolescents Diphtheria Pertussis Tetanus Vaccination |
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