| 优化冠心病抗血小板治疗的策略 |
| |
| 引用本文： | 丁雪燕,秦永文. 优化冠心病抗血小板治疗的策略[J]. 药学服务与研究, 2011, 11(6): 405-408 |
| |
| 作者姓名： | 丁雪燕 秦永文 |
| |
| 作者单位： | 1. 第二军医大学长海医院心血管内科,上海200433;南京军区杭州疗养院海勤疗区特勤科,杭州310002
2. 第二军医大学长海医院心血管内科,上海,200433 |
| |
| 摘 要： | 阿司匹林联合氯吡格雷是目前治疗急性冠状动脉综合征和接受了经皮冠状动脉介入术后抗血小板方案中最佳的组合。然而,出血和部分病人出现不敏感或对抗,促使寻找更理想的抗血小板药物或更优化的治疗方案。高剂量氯吡格雷给药策略虽然轻度增加大出血风险,但有助于更强地抑制血小板功能、改善临床结果。更新、更有效的抗血小板药物,如普拉格雷和替卡格雷,在急性冠状动脉综合征和接受了经皮冠状动脉介入术病人中有更好的短期和长期收益。本文就有关研究进展作简要的综述。
|
| 关 键 词： | 冠心病 血小板聚集抑制剂 药物疗法 |
The research of optimizing antiplatelet therapy of coronary atherosclerotic heart disease |
| |
| DING XueYan , QIN YongWen. The research of optimizing antiplatelet therapy of coronary atherosclerotic heart disease[J]. Pharmaceutical Care and Research, 2011, 11(6): 405-408 |
| |
| Authors: | DING XueYan QIN YongWen |
| |
| Affiliation: | DING XueYan1,2,QIN YongWen1*(1.Department of Cardiovasology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China,2.Department of Special Logistics,Naval Logistic Recuperate Region,Hangzhou Sanatorium of Nanjing Military Region of PLA,Hangzhou 310002,China) |
| |
| Abstract: | Dual antiplatelet therapy with aspirin and clopidogrel is the standard of care for patients with acute coronary syndrome(ACS) and those who undergoing percutaneous coronary intervention(PCI).However,clopidogrel has drawbacks which leads to find the ideal antiplatelet therapy.The higher-than-standard clopidogrel dosing regimens provided greater inhibition of platelet function and improved clinical outcomes with a small but significant increase in major bleeding.Newer,more potent antiplatelet agents such as p... |
| |
| Keywords: | coronary heart disease platelet aggregation inhibitors drug therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
