| Goniotriol和8a-Isogoniotriol的合成 |
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| 引用本文： | 陈虹,刘振华,李灵芝,胡迎庆,吴芳,严黎,韩光. Goniotriol和8a-Isogoniotriol的合成[J]. 武警医学院学报, 2001, 10(1): 1-3 |
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| 作者姓名： | 陈虹 刘振华 李灵芝 胡迎庆 吴芳 严黎 韩光 |
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| 作者单位： | 1. 武警医学院药学教研室
2. 武警医学院药学教研室 总医院 |
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| 基金项目： | 天津市自然科学基金资助课题(003608611) |
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| 摘 要： | 目的Goniotriol是从番荔枝科哥纳香属植物Goniothalamussesquipedalis，all(Annonaceae)分离得到具有抗肿瘤活性的化合物，为了合成抗肿瘤化合物，改进合成路进行本实验研究。方法以α-D-葡庚糖酸-δ-内酯为原料，经8步反应对其进行了合成研究。结果根据药物设计原理，设计合成了Goniotriol和它的8位差向异构体8α-isogoniotriol,总产率分别为7.4％和14.3％。结论该合成路线可容易地合成目标化合物.
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| 关 键 词： | Goniotriol 8α-isogoniotriol 抗肿瘤活性 |
| 文章编号： | 1008-5041(2001)01-0001-03 |
| 修稿时间： | 2000-01-02 |
Synthesis of Goniotrioland 8 |
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| CHEN Hong,LIU Zhen hua,LI Ling zhi,et al.. Synthesis of Goniotrioland 8[J]. Acta Academiae Medicinae CPAPF, 2001, 10(1): 1-3 |
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| Authors: | CHEN Hong LIU Zhen hua LI Ling zhi et al. |
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| Affiliation: | CHEN Hong,LIU Zhen hua,LI Ling zhi,et al.Department of Pharmacy,Medical College of Chinese People's Armed Police Forces.Tianjin 300162 |
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| Abstract: | Objective: To explore the syntheses of Goniotriol with antitumor was isolated from Goniothalamus sesquipedalis, Wall (Annonaceae). Methods: The compound was synthesized by eight steps from commercially available D-glycer-D-gulo-heptono-γ-lactone. Results: Goniotriol and 8α-Isogoniotriol were synthesized and the total yield was in 7.4% and 14.3% respechively. Conclusion: The synthetic route is easy and simple. |
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