Association of the Tau haplotype with Parkinson's disease in the Greek population. |
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Authors: | Liana Fidani Kallirhoe Kalinderi Sevasti Bostantjopoulou Jordi Clarimon Antonis Goulas Zoe Katsarou John Hardy Alexandros Kotsis |
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Affiliation: | Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. lfidani@med.auth.gr |
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Abstract: | We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03-2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. |
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Keywords: | Tau polymorphisms haplotypes Parkinson's disease |
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