婴幼儿抗生素相关性腹泻的危险因素分析

目的探讨住院婴幼儿抗生素相关性腹泻(AAD)的危险因素及其防治策略。方法对2008年1月至2010年1月在本院住院、应用抗菌药物治疗的1450例婴幼儿进行回顾性分析。结果 85例住院婴幼儿发生AAD,发生率5.86%,AAD与患儿体重低、年龄小、应用≥2种抗菌药物、应用3代头孢霉素、应用抗菌药物时间长、白细胞升高、C反应蛋白升高、合并重要脏器损害、住院时间长有关(P<0.05或P<0.01),与性别、应用抗菌药物种类无关(P>0.05),预防性应用微生态制剂可以减少AAD(P<0.05)。结论婴幼儿抗生素相关性腹泻的发生率高,加强预防措施,尽量避免危险因素、合理应用抗菌药物、预防性应用微生态制剂是减少住院婴幼儿AAD的关键。

Danger Factors to Antibiotic Associated Diarrhea in Infants and Young Children

Objective To investigate the danger factors in antibiotic associated diarrhea(AAD) of infant and young children,and its prevention and management.Methods Totally 1450 infant and young children patients who received antibiotic therapy in our hospital from January 2008 to January 2010 were analysed retrospectively.Results The incidence of AAD were 85 cases(5.86%).The danger factors were low avoirdupois,little age,applied two or above two antibiotic,the third generations of cephalosporins,length of applied ant...