| 拉莫三嗪对难治性精神分裂症患者认知功能的影响 |
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| 引用本文： | 龙金亮,孙群星,刘勇,朱玉星.拉莫三嗪对难治性精神分裂症患者认知功能的影响[J].中国实用医药,2011,6(8):3-5. |
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| 作者姓名： | 龙金亮 孙群星 刘勇 朱玉星 |
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| 作者单位： | 河南省驻马店市精神病院,463000 |
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| 摘 要： | 目的探讨拉莫三嗪对难治性精神分裂症患者认知功能的影响。方法采用入院顺序分层随机法,将80例难治性精神分裂症患者平均分为研究组(拉莫三嗪+利培酮)和对照组(利培酮+安慰剂)。在治疗前和治疗后2、4、8、12周末,用阳性症状及阴性症状量表(PANSS),不良反应量表(TESS)评定疗效及副反应,用韦氏成人智力量表(WAIS-R)、韦氏记忆量表(WMS)评定治疗前后患者认知功能的改变。分析量表中各领域的计分。结果两组PANSS总分在治疗后与治疗前比较差异存在统计学意义(P<0.05),研究组有效率72.5%,显效率20%;对照组有效率52.5%,显效率12.5%。两组间疗效差异有统计学意义(P<0.05),且两组言语量表、操作量表、全量表和记忆量表分比治疗前明显提高,研究组与对照组比较差异有统计学意义(P<0.05)。治疗后2、4、8、12周末TESS评分,两组差异无统计学意义(P>0.05)。结论拉莫三嗪合并利培酮治疗难治性精神分裂症疗效确切,且安全性高,对认知功能的改善彻底。
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| 关 键 词： | 拉莫三嗪 精神分裂症 认知功能 |
Effect of Lamotrigine on Cognitive Function in Patients with Refractory Schizophrenia |
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| LONG Jin-liang,SUN Qun-xing,LIU Yong. et al.Effect of Lamotrigine on Cognitive Function in Patients with Refractory Schizophrenia[J].China Practical Medical,2011,6(8):3-5. |
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| Authors: | LONG Jin-liang SUN Qun-xing LIU Yong |
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| Institution: | LONG Jin-liang,SUN Qun-xing,LIU Yong. et al.Mental Hospital of Zhumadian Henan 463000,China |
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| Abstract: | Objective To investigate the effect of Lamotrigine (LTG) on cognitive function in patients with refractory schizophrenia. Methods Being used a stratified random method according to the order of admission, 80 patients with refractory schizophrenia were divided into study group (LTG + risperidone) and control group (risperidone + placebo). The Positive and Negative Syndrome Scale(PANSS) and treatment emergent symptom scale(TESS) were used to evaluate the efficacy and side effects respectively at baseline and ... |
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| Keywords: | Lamotrigine Schizophrenia Cognitive function |
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