胃癌患者螺旋CT Lauren 分型与磷酸酶蛋白的表达

目的:将胃癌螺旋CT(SCT) Lauren 分型与磷酸酶基因(PTEN)的表达相对照,探讨胃癌SCT表现的分子病理学基础.方法:对83例进展期胃癌患者行SCT平扫及三期动态增强扫描后进行Lauren分型.所有病例均于检查后1周内手术.术后标本行HE染色进行病理学诊断,并与SCT的分型行一致性检验,采用免疫组织化学方法对SCT分型后的标本进行PTEN蛋白检测.结果:①83例胃癌病理学诊断肠型39例,弥漫型44例;SCT诊断肠型40例,弥漫型43例,SCT对胃癌Lauren分型的诊断正确率为96.3%,二者分型基本一致(Kappa=0.928,P＜0.05).②弥漫型与肠型胃癌组织中PTEN蛋白阳性表达率分别为32.6%和62.5%,2者差异有统计学意义(P＜0.05).结论:SCT增强扫描与分子生物学相结合可提高对胃癌侵袭、转移和预后评估的准确性.

Correlation between Lauren classification by spiral CT and expression of PTEN in gastric carcinoma tissue

Aim:To compare Lauren classification by SCT with expressions of PTEN in gastric carcinoma tissue so as to investigate the molecular pathologic basement of SCT features of gastric carcinoma.Methods:A total of 83 patients with gastric carcinoma accepted operation within one week after SCT scan.The expression of PTEN in specimens was detected using immunohistochemistry.Results:The accuracy of SCT for Lauren classification was 96.3%.The pathological typing results was consistent with the Lauren classification results by SCT(Kappa=0.928,P<0.05).In the 83 cases of gastric carcinomas,the PTEN-positive expression rates in the diffused and intestinal gastric carcinoma were 32.6% and 62.5%,and the differences were statistically significant(P<0.05).Conclusion:Enhanced SCT scan combined with pathological technique might improve diagnostic accuracy of invasion and metastasis and prognosis in gastric carcinoma.