| FGF-1分泌途径的研究进展 |
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| 引用本文： | 洪灿,曹仁贤.FGF-1分泌途径的研究进展[J].国际病理科学与临床杂志,2008,28(6):18-543. |
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| 作者姓名： | 洪灿 曹仁贤 |
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| 作者单位： | 南华大学附属第一医院临床医学研究所,湖南 衡阳,421001 |
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| 基金项目： | 湖南省自然科学基金(06JJ50046) This work was supported by Natural Science Foundation of Hunan Province of P. R. China
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| 摘 要： | 酸性成纤维生长因子-1（FGF-1）由于氨基端缺乏信号肽序列，不能通过经典的内质网-高尔基体途径释放。但在一些应激条件下，FGF-1与S100A13, P40syt1, SK1结合成多蛋白释放复合体，实现跨磷脂膜的出胞转运。FGF-1与许多病理过程有关，因而一些干预FGF-1释放途径的措施为治疗FGF-1介导的疾病提供了新的思路。
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| 关 键 词： | 酸性成纤维生长因子-1 非经典释放 多蛋白释放复合体 |
| 收稿时间： | 2008-5-30 |
| 修稿时间： | 2008-8-19 |
Progression of the secretory pathway of FGF-1 |
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| HONG Can,CAO Ren-xian.Progression of the secretory pathway of FGF-1[J].Journal of International Pathology and Clinical Medicine,2008,28(6):18-543. |
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| Authors: | HONG Can CAO Ren-xian |
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| Institution: | Institude of Clinical Research Department, First Affiliated Hospital of Nanhua University, Hengyang Hunan 42100, China |
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| Abstract: | Fibroblast growth factor(FGF-1)lacks amino-terminal signal peptide,so it can't release through the classical endoplasmic reticulum(ER)-Golgi pathway.Under some stresses,FGF-1 binds S00A13,P40Syt1,and SK1 to be a multiprotein release complex that is released into extracellular compartment across membrane.FGF-1 is involved in many pathological processes,so the measures to disturb or inhibit FGF-1 release pathway provide a new strategy for the diseases directed by FGF-1. |
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| Keywords: | fibroblast growth factor-1 non-classical release multiprotein release complex |
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