北京市石景山区居民血尿酸水平与慢性病关系探讨

目的了解人群血尿酸水平和高尿酸血症(Hyperuricemia,HUA)患病状况及与性别、年龄等慢病危险因素的关系。方法对北京市石景山区居民进行成人HUA患病及危险因素调查,测定血尿酸、血糖、血脂水平,测量身高、体重、腰围,分析血尿酸水平与慢性病及危险因素之间的关系。结果血尿酸水平各年龄段男性均高于女性,血尿酸随年龄升高而升高,差异有统计学意义;血尿酸水平与高血压、血脂异常、心脑血管病、TG、TC、HDL-C、和超重肥胖相关。HUA患病率为11.1%,其中男性患病率18.2%,女性患病率6.7%,男性高于女性,差异有统计学意义(χ2=121.789,P=0.000);主要患病年龄在40～49岁,50岁以上患病率低;HUA患病率与吸烟、饮酒密切相关,logistic回归分析,男性、饮酒、高TG、低HDL是HUA危险因素。结论血尿酸水平与血脂异常、高血压、肥胖等慢病相关,而且与吸烟、饮酒等生活方式有关,改善生活方式和饮食习惯,对降低血尿酸水平,预防心脑血管病是有益的。

Analysis of the relationship between serum uric acid levels and chronic diseases among residents in Shijingshan district,Beijing

Objective To understand the serum uric acid levels and the prevalence of Hyperuricemia（HUA）in residents,and their relationships with gender,age and other risk factors for chronic diseases.Methods The prevalence and the risk factors of HUA were investigated among adult residents in Shijingshan district.Data of serum uric acid,blood glucose,blood lipid,height,weight,and waist were tested and collected.Moreover,the relationships between the levels of serum uric acid and chronic diseases,including their risk factors,were analysed.Results Serum uric acid levels for males in all age groups were significant higher than that for females.The levels of serum uric acid increased with age growing.Serum urate status correlated with hypertension,Dyslipidemia,cardiovascular disease,TG,TC,HDL-C,overweight and obesity.The prevalence of HUA was 11.1% and the rate for males was higher than that for females（male 18.2%,female 6.7%.χ2=121.789,p=0.000）.Most patients belonged to 40~49 years old and the incidence for persons over 50 years old was low.The occurrence of HUA was closely related with smoking and drinking.Male,alcohol intake,high TG,and low HDL were the risk factors of HUA which confirmed through Logistic regression analysis.Conclusion Serum uric acid levels correlated with chronic diseases such as dyslipidemia,high blood pressure and obesity.Meanwhile,serum urate status was also related with lifestyles such as smoking and alcohol consumption.Improving lifestyle and diet would be beneficial to lower serum uric acid levels and prevent cardio-cerebral-vascular disease.