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The involvement of 6p in melanoma |
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| Authors: | Janet M. Cowan Ruth Halaban Alfred T. Lane Uta Francke |
| Affiliation: | a Department of Human Genetics, Yale University School of Medicine, New Haven, CT, USA b Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA c University of Rochester Medical Center, Rochester, N.Y., USA |
| Abstract: | Karyotype analysis of first passage cells from a melanoma, occurring in a patient with a giant congenital nevus, revealed monosomy of chromosomes #6 and #11, and trisomy of chromosomes #8 and #22. Five marker chromosomes were present, including two ring chromosomes. The origin of three of the marker chromosomes was determined, and all were found to contain the region 6p21.1–6p23. The ring chromosomes were also thought to contain this region, to which the major histocompatibility locus has been mapped. The significance of these findings is discussed in the light of recent reports of chromosome studies of melanoma cells. |
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